iPTMnet Report for Q9Y697 (NFS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y697 / NFS1_HUMAN
Protein Name Cysteine desulfurase precursor
Gene Name Name: NFS1
Synonyms:NIFS;ORFNames:HUSSY-08;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y697
DAG View
PRO Name cysteine desulfurase (human)
Definition A cysteine desulfurase NFS1 that is encoded in the genome of human.
Short Label hNFS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y697 (NFS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T26 Phosphorylation PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
Y269 Phosphorylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
T397 Phosphorylation PhosphoSitePlus
T414 Phosphorylation PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
Y421 Phosphorylation PhosphoSitePlus
T422 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
C426 Methylation IEDB 31844290
S437 Phosphorylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K147 R147 Biomuta DOID:1324 / lung cancer [ cosmic ]
K157 T157 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K239 T239 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K258 R258 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T414 A414 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K425 R425 Biomuta DOID:363 / uterine cancer [ icgc ]
S451 N451 Biomuta DOID:363 / uterine cancer [ icgc ]
K453 N453 Biomuta DOID:363 / uterine cancer [ icgc ]