iPTMnet Report for Q9Y616 (IRAK3)
Protein Information
| UniProt AC / UniProt ID | Q9Y616 / IRAK3_HUMAN |
| Protein Name | Interleukin-1 receptor-associated kinase 3 |
| Gene Name | Name: IRAK3 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9Y616 |
| PRO Name | interleukin-1 receptor-associated kinase 3 (human) |
| Definition | An interleukin-1 receptor-associated kinase 3 that is encoded in the genome of human. |
| Short Label | hIRAK3 |
| Category | organism-gene |
DAG ViewQ9Y616 (IRAK3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y61 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S67 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S110 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 29686383 | ||
| S115 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S154 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T162 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T188 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y189 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K199 | Acetylation | score1 | PhosphoSitePlus | |||
| S335 | Phosphorylation | score1 | IEDB | 30784271 | ||
| K379 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S398 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S401 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S467 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| S484 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S510 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S512 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S551 | O-Glycosylation | score1 | GlyGen | 30379171 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S49 | Phosphorylation | score1 | PhosphoSitePlus |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:Q9Y616-1 (hIRAK3/iso:1) | Interaction | PR:Q99836 (hMYD88) | PRO | 10383454 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S49 | I49 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| Y61 | H61 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] | |
| S67 | N67 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| S110 | I110 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| T188 | I188 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S398 | L398 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S401 | P401 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
| S401 | L401 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S510 | N510 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| S512 | A512 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S551 | F551 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] |
