Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y608 / LRRF2_HUMAN
Protein Name Leucine-rich repeat flightless-interacting protein 2
Gene Name Name: LRRFIP2
Organism Homo sapiens (Human)

PRO ID PR:Q9Y608
DAG View
PRO Name leucine-rich repeat flightless-interacting protein 2 (human)
Definition A leucine-rich repeat flightless-interacting protein 2 that is encoded in the genome of human.
Short Label hLRRFIP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y608 (LRRFIP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R8 Methylation PhosphoSitePlus
T11 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus   UniProt 20068231
S25 Phosphorylation PhosphoSitePlus
Y111 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
Y184 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus   UniProt 21220426
S200 Phosphorylation PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21220426
S205 Phosphorylation PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus
Y225 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
Y267 Phosphorylation PhosphoSitePlus
Y300 Phosphorylation PhosphoSitePlus
Y304 Phosphorylation PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus   UniProt 23186163
S312 Phosphorylation PhosphoSitePlus   UniProt 24275569
T317 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 19690332
S323 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332, 24275569
R326 Methylation PhosphoSitePlus
S328 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18669648, 24275569, 17693683, 19690332, 20068231
T331 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S332 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S333 Phosphorylation PhosphoSitePlus
T339 Phosphorylation phospho.ELM 18669648
S340 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
Y348 Phosphorylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
Y398 Phosphorylation PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation HPRD 19651622, 20068231
S320 Phosphorylation HPRD 19413330, 19651622, 19664995, ...20068231
S323 Phosphorylation HPRD 19413330, 19651622, 19664995, ...20068231
S324 Phosphorylation HPRD 19413330, 19651622, 20068231
S328 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 17693683, 20166139, 20068231
T331 Phosphorylation HPRD 18669648, 20068231, 18452278
S332 Phosphorylation HPRD 18669648, 17081983
S333 Phosphorylation HPRD 17081983, 20068231, 18452278
T339 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation HPRD 19651622, 20068231
Y68 Phosphorylation PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
S88 Phosphorylation HPRD 19413330, 19651622, 19664995, ...20068231
S91 Phosphorylation HPRD 19413330, 19651622, 19664995, ...20068231
S92 Phosphorylation HPRD 19413330, 19651622, 20068231
S96 Phosphorylation HPRD   PhosphoSitePlus 17081983, 18452278, 19651622, ...18669648, 17693683, 20166139, 20068231
T99 Phosphorylation HPRD 18669648, 20068231
S100 Phosphorylation HPRD 18669648, 17081983
S101 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
T107 Phosphorylation HPRD   PhosphoSitePlus 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y111 N111 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
S190 F190 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S200 R200 Biomuta DOID:1324 / lung cancer [ tcga ]
S232 * Biomuta DOID:3571 / liver cancer [ icgc ]
S250 F250 Biomuta DOID:3070 / malignant glioma [ tcga ]
T317 I317 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T317 N317 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S328 R328 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S332 N332 Biomuta DOID:363 / uterine cancer [ tcga ]
Y398 F398 Biomuta DOID:1324 / lung cancer [ cosmic ]
S615 * Biomuta DOID:1324 / lung cancer [ cosmic ]