iPTMnet Report for Q9Y606 (PUS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y606 / PUS1_HUMAN
Protein Name Pseudouridylate synthase 1 homolog precursor
Gene Name Name: PUS1
ORFNames:PP8985;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y606
DAG View
PRO Name pseudouridylate synthase 1 homolog (human)
Definition A eukaryotic tRNA pseudouridine synthase A that is encoded in the genome of human.
Short Label hPUS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y606 (PUS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K110 Ubiquitination PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
Y239 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K364 Ubiquitination PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus   UniProt 20068231
S420 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231
T426 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231, 16964243
Site PTM Type PTM Enzyme Score Source PMID
T221 Phosphorylation HPRD 20068231
Y239 Phosphorylation HPRD 18083107
S415 Phosphorylation HPRD 19413330, 20068231
S420 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231, 19664995
T426 Phosphorylation HPRD 19413330, 17322306, 16964243, ...18767875, 19664995, 19651622, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T193 Phosphorylation HPRD 20068231
Y211 Phosphorylation HPRD 18083107
S387 Phosphorylation HPRD 19413330, 20068231
S392 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231, 19664995
T398 Phosphorylation HPRD 19413330, 17322306, 16964243, ...18767875, 19664995, 19651622, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S138 F138 Biomuta DOID:4159 / skin cancer [ cosmic ]
S150 F150 Biomuta DOID:1612 / breast cancer [ cosmic ]
S176 F176 Biomuta DOID:4159 / skin cancer [ cosmic ]