iPTMnet Report for Q9Y5T5 (USP16)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y5T5 / UBP16_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 16
Gene Name Name: USP16
ORFNames:MSTP039;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y5T5
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 16 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 16 that is encoded in the genome of human.
Short Label hUSP16
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y5T5 (USP16) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K9 Ubiquitination PhosphoSitePlus
T10 Phosphorylation PhosphoSitePlus
K29 Acetylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K37 Acetylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 26323689, 23186163
S199 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus   RLIMS-P 26323689
S330 Phosphorylation P53350 (PLK1) PhosphoSitePlus 26323689
K333 Ubiquitination PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
S386 Phosphorylation IEDB   PhosphoSitePlus   RLIMS-P 26323689, 35494241
S386 Phosphorylation P53350 (PLK1) PhosphoSitePlus 26323689
S415 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 21406692, ...28380042
S423 Phosphorylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus   RLIMS-P 26323689
S486 Phosphorylation P53350 (PLK1) PhosphoSitePlus 26323689
K506 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
S531 Phosphorylation PhosphoSitePlus
T550 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
S552 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 28380042, 15302935, ...24013421, 18669648, 26323689, 19690332, 20068231
S552 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 26323689, 24013421
T554 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 28380042, 20068231
S598 Phosphorylation PhosphoSitePlus
T600 Phosphorylation PhosphoSitePlus
Y606 Phosphorylation PhosphoSitePlus
Y742 Phosphorylation PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T145 Phosphorylation HPRD 20068231
S415 Phosphorylation HPRD 19651622, 20166139, 18669648, ...18452278
T550 Phosphorylation HPRD 20058876
S551 Phosphorylation HPRD 20058876, 20068231
S552 Phosphorylation HPRD 17322306, 19413330, 18669648, ...20058876, 20068231
T554 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
T600 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T145 Phosphorylation HPRD 20068231
S414 Phosphorylation HPRD 19651622, 20166139, 18669648, ...18452278
T549 Phosphorylation HPRD 20058876
S550 Phosphorylation HPRD 20058876, 20068231
S551 Phosphorylation HPRD 17322306, 19413330, 18669648, ...20058876, 20068231
T553 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
T599 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S330 F330 Biomuta DOID:1612 / breast cancer [ icgc ]
K333 N333 Biomuta DOID:3571 / liver cancer [ cosmic ]
K333 T333 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S486 T486 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K506 T506 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S598 G598 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:1324 / lung cancer [ cosmic ]