iPTMnet Report for Q9Y5S2 (CDC42BPB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y5S2 / MRCKB_HUMAN
Protein Name Serine/threonine-protein kinase MRCK beta
Gene Name Name: CDC42BPB
Synonyms:KIAA1124;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y5S2
DAG View
PRO Name serine/threonine-protein kinase MRCK beta (human)
Definition A serine/threonine-protein kinase MRCK beta that is encoded in the genome of human.
Short Label hCDC42BPB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y5S2 (CDC42BPB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T118 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
T423 Phosphorylation PhosphoSitePlus   UniProt 24275569
K426 Ubiquitination PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
K489 Acetylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
S659 Phosphorylation PhosphoSitePlus
K665 Ubiquitination PhosphoSitePlus
R671 Methylation PhosphoSitePlus   UniProt 24129315
T676 Phosphorylation PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
T757 Phosphorylation PhosphoSitePlus
K789 Ubiquitination PhosphoSitePlus
K807 Ubiquitination PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
T843 Phosphorylation PhosphoSitePlus
S851 Phosphorylation PhosphoSitePlus
S852 Phosphorylation HPRD 20068231
T858 Phosphorylation PhosphoSitePlus
K864 Ubiquitination PhosphoSitePlus
S868 Phosphorylation PhosphoSitePlus
K870 Ubiquitination PhosphoSitePlus
K890 Ubiquitination PhosphoSitePlus
K910 Ubiquitination PhosphoSitePlus
S914 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K929 Ubiquitination PhosphoSitePlus
Y954 Phosphorylation PhosphoSitePlus
S1029 Phosphorylation PhosphoSitePlus
K1083 Ubiquitination PhosphoSitePlus
K1099 Ubiquitination PhosphoSitePlus
T1108 Phosphorylation PhosphoSitePlus
Y1118 Phosphorylation PhosphoSitePlus
K1135 Ubiquitination PhosphoSitePlus
T1196 Phosphorylation PhosphoSitePlus
K1202 Ubiquitination PhosphoSitePlus
K1280 Ubiquitination PhosphoSitePlus
K1337 Methylation PhosphoSitePlus
K1337 Ubiquitination PhosphoSitePlus
K1349 Acetylation PhosphoSitePlus
Y1355 Phosphorylation PhosphoSitePlus
C1378 Methylation IEDB 31844290
K1526 Methylation PhosphoSitePlus
K1528 Methylation PhosphoSitePlus
K1528 Ubiquitination PhosphoSitePlus
S1530 Phosphorylation PhosphoSitePlus
K1544 Ubiquitination PhosphoSitePlus
K1559 Ubiquitination PhosphoSitePlus
Y1638 Phosphorylation HPRD   PhosphoSitePlus 18707149
S1640 Phosphorylation PhosphoSitePlus
S1643 Phosphorylation PhosphoSitePlus
S1644 Phosphorylation PhosphoSitePlus
S1647 Phosphorylation PhosphoSitePlus
S1650 Phosphorylation PhosphoSitePlus
T1652 Phosphorylation PhosphoSitePlus
S1659 Phosphorylation PhosphoSitePlus
S1677 Phosphorylation PhosphoSitePlus
T1678 Phosphorylation PhosphoSitePlus
S1680 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1682 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1683 Phosphorylation PhosphoSitePlus
S1686 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1690 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 19651622, 18669648, 20166139, 20068231
S1693 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
C1709 S-Nitrosylation dbSNO 26338901


Q9Y5S2 (CDC42BPB) as PTM Enzyme



Substrate Site Score Source PMID
O14974 (PPP1R12A) S852 neXtProt 10947843, 21457715
P24844 (MYL9) S20 neXtProt 10947843, 21457715
P26038 (MSN) T558 neXtProt   Signor 10947843
P35611 (ADD1) T445 neXtProt 10947843


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S310 C310 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S363 C363 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S474 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S474 L474 Biomuta DOID:1612 / breast cancer [ icgc ]
K489 R489 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S524 F524 Biomuta DOID:4159 / skin cancer [ cosmic ]
K571 N571 Biomuta DOID:1324 / lung cancer [ cosmic ]
R671 Q671 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K807 N807 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S852 F852 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1083 R1083 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y1118 N1118 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y1118 * Biomuta DOID:263 / kidney cancer [ cosmic ]
K1202 N1202 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K1337 Q1337 Biomuta DOID:363 / uterine cancer [ cosmic ]
S1644 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1647 L1647 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1652 I1652 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1677 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
T1678 I1678 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1683 C1683 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1693 C1693 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]