iPTMnet Report for Q9Y5L0 (TNPO3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y5L0 / TNPO3_HUMAN
Protein Name Transportin-3
Gene Name Name: TNPO3
Synonyms:IPO12;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y5L0
DAG View
PRO Name transportin-3 (human)
Definition A transportin-3 that is encoded in the genome of human.
Short Label hTNPO3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y5L0 (TNPO3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
K27 Ubiquitination PhosphoSitePlus
C60 Methylation IEDB 31844290
K68 Ubiquitination PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus   UniProt 23186163
K291 Ubiquitination PhosphoSitePlus
C303 Methylation IEDB 31844290
K513 Ubiquitination PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
C527 Methylation IEDB 31844290
S554 Phosphorylation PhosphoSitePlus
C580 Methylation IEDB 31844290
K594 Acetylation PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
C634 S-Nitrosylation dbSNO 26338901
K877 Ubiquitination PhosphoSitePlus
K881 Ubiquitination PhosphoSitePlus
T891 Phosphorylation PhosphoSitePlus
K893 Ubiquitination PhosphoSitePlus
T896 Phosphorylation PhosphoSitePlus   UniProt 19690332
K900 Acetylation PhosphoSitePlus
K900 Ubiquitination PhosphoSitePlus
K909 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T501 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K513 M513 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K521 N521 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C527 * Biomuta DOID:3571 / liver cancer [ cosmic ]
C580 S580 Biomuta DOID:1324 / lung cancer [ cosmic ]
K594 R594 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K594 N594 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C634 G634 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T891 S891 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K900 N900 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]