iPTMnet Report for Q9Y5K6 (CD2AP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y5K6 / CD2AP_HUMAN
Protein Name CD2-associated protein
Gene Name Name: CD2AP
Organism Homo sapiens (Human)

PRO ID PR:Q9Y5K6
DAG View
PRO Name CD2-associated protein (human)
Definition A CD2-associated protein that is encoded in the genome of human.
Short Label hCD2AP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y5K6 (CD2AP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K55 Acetylation PhosphoSitePlus
K58 Sumoylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus   UniProt 23186163
K71 Ubiquitination PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus   UniProt 23186163
S86 Phosphorylation PhosphoSitePlus   UniProt 23186163
T87 Phosphorylation PhosphoSitePlus
Y88 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455, 16497976
K102 Ubiquitination PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
S189 Phosphorylation HPRD   PhosphoSitePlus 18452278
K221 Ubiquitination PhosphoSitePlus
S224 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 20166139, 18669648, 23186163, ...21406692
K226 Ubiquitination PhosphoSitePlus
T229 Phosphorylation PhosphoSitePlus
T231 Phosphorylation HPRD   PhosphoSitePlus 20068231
S232 Phosphorylation PhosphoSitePlus
S233 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S234 Phosphorylation PhosphoSitePlus
T236 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
T260 Phosphorylation HPRD 18767875
T262 Phosphorylation HPRD 18767875
T264 Phosphorylation HPRD 18767875
K333 Ubiquitination PhosphoSitePlus
K359 Acetylation PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K360 Acetylation PhosphoSitePlus
Y361 Phosphorylation HPRD   PhosphoSitePlus 17016520, 18707149
S363 Phosphorylation HPRD   PhosphoSitePlus 18212344
K365 Ubiquitination PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus
T396 Phosphorylation PhosphoSitePlus
K397 Methylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
Y409 Phosphorylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
K425 Acetylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
K446 Acetylation PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
S458 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18212344, ...18220336, 19664994, 20058876, 19664995, 18452278, 19651622, 18669648, 24275569, 18088087, 19690332, 20068231
S463 O-Glycosylation GlyGen 23301498, 31492838, 35132862, ...34019948
S463 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T465 Phosphorylation PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
K495 Methylation PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
S510 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 21406692, 23186163, ...17081983, 19664995, 17322306, 20068231
T512 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S514 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 21406692, 23186163, ...20068231
T539 Phosphorylation PhosphoSitePlus
C540 Methylation IEDB 31844290
C540 S-Nitrosylation dbSNO 26338901
Y541 Phosphorylation HPRD   PhosphoSitePlus 16497976
S542 O-Glycosylation GlyGen 23301498, 31492838, 35132862, ...34019948
S542 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K544 Ubiquitination PhosphoSitePlus
S546 O-Glycosylation GlyGen 23301498, 31492838, 35132862, ...34019948
S546 Phosphorylation PhosphoSitePlus
Y548 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16497976
S550 Phosphorylation PhosphoSitePlus
T551 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 20068231
S553 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S554 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 20068231
S556 Phosphorylation HPRD   PhosphoSitePlus 20068231
K557 Ubiquitination PhosphoSitePlus
T565 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163, 19664995
K570 Ubiquitination PhosphoSitePlus
S582 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
K613 Ubiquitination PhosphoSitePlus
K631 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K55 N55 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K58 E58 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S189 L189 Biomuta DOID:4159 / skin cancer [ cosmic ]
K221 E221 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S224 C224 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S232 P232 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S233 T233 Biomuta DOID:263 / kidney cancer [ cosmic ]
S234 R234 Biomuta DOID:3571 / liver cancer [ cosmic ]
T260 K260 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T264 S264 Biomuta DOID:1324 / lung cancer [ cosmic ]
K415 R415 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K436 Q436 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S510 F510 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C540 W540 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y541 H541 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S546 A546 Biomuta DOID:363 / uterine cancer [ cosmic ]
S582 C582 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S582 F582 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
K613 T613 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K613 N613 Biomuta DOID:1324 / lung cancer [ cosmic ]