Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y5J3 / HEY1_HUMAN
Protein Name Hairy/enhancer-of-split related with YRPW motif protein 1
Gene Name Name: HEY1
Synonyms:BHLHB31,CHF2,HERP2,HESR1,HRT1;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y5J3
DAG View
PRO Name hairy/enhancer-of-split related with YRPW motif protein 1 (human)
Definition A hairy/enhancer-of-split related with YRPW motif protein 1 that is encoded in the genome of human.
Short Label hHEY1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y5J3 (HEY1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
K59 Acetylation PhosphoSitePlus
S68 Phosphorylation RLIMS-P 27129302
S78 Phosphorylation PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S246 Phosphorylation RLIMS-P 27129302
Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation HPRD 19413330
S45 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation HPRD 19413330
S45 Phosphorylation HPRD 19413330


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9Y5J3 (HEY1) S68 Q00987 (MDM2) decreased_association eFIP 27129302
Phosphorylation Q9Y5J3 (HEY1) S68 P62913 (RPL11) inhibited_association eFIP 27129302
Phosphorylation Q9Y5J3 (HEY1) S68 P04637 (TP53) increased_association eFIP 27129302


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 * Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S13 R13 Biomuta DOID:3571 / liver cancer [ icgc ]
S45 P45 Biomuta DOID:3070 / malignant glioma [ tcga ]
S45 F45 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]