iPTMnet Report for Q9Y5B9 (SUPT16H)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y5B9 / SP16H_HUMAN
Protein Name FACT complex subunit SPT16
Gene Name Name: SUPT16H
Synonyms:FACT140,FACTP140;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y5B9
DAG View
PRO Name FACT complex subunit SPT16 (human)
Definition A FACT complex subunit SPT16 that is encoded in the genome of human.
Short Label hSUPT16H
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y5B9 (SUPT16H) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
K7 Acetylation PhosphoSitePlus
K7 Ubiquitination PhosphoSitePlus
R12 Methylation PhosphoSitePlus
R13 Methylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
K139 Acetylation PhosphoSitePlus   UniProt 19608861
K139 Ubiquitination PhosphoSitePlus
K156 Acetylation PhosphoSitePlus
K156 Methylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
S165 O-Glycosylation GlyGen 33465208
T171 O-Glycosylation GlyGen 23301498, 33214551, 32522876, ...35138101, 30379171, 34725712, 29351928, 34019948, 32119511, 28510447, 33465208
K185 Ubiquitination PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S191 Phosphorylation PhosphoSitePlus
K196 Acetylation PhosphoSitePlus   UniProt 19608861
K196 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K211 Acetylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K216 Acetylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
S220 O-Glycosylation GlyGen 23301498, 33214551, 32522876, ...35138101, 30379171, 34725712, 29351928, 34019948, 32119511, 28510447, 33465208
K223 Acetylation PhosphoSitePlus   UniProt 19608861
K223 Ubiquitination PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
K280 Acetylation PhosphoSitePlus
K280 Methylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
C283 Methylation IEDB 31844290
Y326 Phosphorylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K392 Acetylation PhosphoSitePlus
K422 Sumoylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K433 Sumoylation PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus   UniProt 23186163
K479 Sumoylation PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
T494 Phosphorylation PhosphoSitePlus 22267324
T494 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus 22267324
K497 Sumoylation PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
S508 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K513 Acetylation PhosphoSitePlus   UniProt 19608861
K513 Sumoylation PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
K528 Acetylation PhosphoSitePlus
Y535 Phosphorylation PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
S558 Phosphorylation HPRD 20068231
Y565 Phosphorylation PhosphoSitePlus
T566 Phosphorylation PhosphoSitePlus
Y567 Phosphorylation PhosphoSitePlus
C574 Methylation IEDB 31844290
T593 Phosphorylation PhosphoSitePlus
K596 Acetylation PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
T599 Phosphorylation PhosphoSitePlus
Y600 Phosphorylation PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
K626 Acetylation PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
T634 Phosphorylation PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
K647 Sumoylation PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
S650 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 19691289, ...18669648, 20068231
S658 Phosphorylation PhosphoSitePlus   UniProt 23186163
K661 Acetylation PhosphoSitePlus
K663 Acetylation PhosphoSitePlus
K663 Sumoylation PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
K674 Acetylation PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
K696 Ubiquitination PhosphoSitePlus
K732 Acetylation PhosphoSitePlus   UniProt 19608861
K732 Ubiquitination PhosphoSitePlus
Y741 Phosphorylation PhosphoSitePlus
K753 Ubiquitination PhosphoSitePlus
R760 Methylation PhosphoSitePlus
Y764 Phosphorylation PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
K781 Acetylation PhosphoSitePlus
K781 Ubiquitination PhosphoSitePlus
K786 Acetylation PhosphoSitePlus   UniProt 19608861
K786 Ubiquitination PhosphoSitePlus
K792 Ubiquitination PhosphoSitePlus
C815 Methylation IEDB 31844290
Y861 Phosphorylation PhosphoSitePlus
Y864 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus
K867 Ubiquitination PhosphoSitePlus
K883 Ubiquitination PhosphoSitePlus
K892 Ubiquitination PhosphoSitePlus
T903 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19664994, 23186163, 20068231
K904 Acetylation PhosphoSitePlus   UniProt 19608861
K904 Ubiquitination PhosphoSitePlus
K907 Ubiquitination PhosphoSitePlus
S979 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17081983, ...19651622, 20068231
S982 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 19651622, 20068231
S986 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17081983, ...19651622, 20068231
S1004 Phosphorylation PhosphoSitePlus
Y1006 Phosphorylation PhosphoSitePlus
S1013 Phosphorylation PhosphoSitePlus
R1014 Methylation PhosphoSitePlus
S1015 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1017 Phosphorylation PhosphoSitePlus
S1023 Phosphorylation HPRD   PhosphoSitePlus 19651622
S1026 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S1027 Phosphorylation HPRD   PhosphoSitePlus 19651622
R1029 Methylation PhosphoSitePlus
S1031 Phosphorylation PhosphoSitePlus
R1033 Methylation PhosphoSitePlus
S1035 O-Glycosylation GlyGen 33465208
R1036 Methylation PhosphoSitePlus
S1038 O-Glycosylation GlyGen 33465208
S1038 Phosphorylation HPRD   PhosphoSitePlus 18510355, 20068231
S1039 O-Glycosylation GlyGen 23301498, 33214551, 32522876, ...35138101, 30379171, 34725712, 29351928, 34019948, 32119511, 28510447, 33465208
S1039 Phosphorylation HPRD   PhosphoSitePlus 18510355


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R12 L12 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
R13 Q13 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K120 R120 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S138 R138 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K392 E392 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y535 C535 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K696 R696 Biomuta DOID:363 / uterine cancer [ icgc ]
K732 N732 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K792 R792 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K792 Q792 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y864 C864 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1319 / brain cancer [ cosmic ]
K883 N883 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K907 N907 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1006 S1006 Biomuta DOID:1612 / breast cancer [ cosmic ]
R1014 Q1014 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S1027 L1027 Biomuta [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
R1029 H1029 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R1029 C1029 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R1033 S1033 Biomuta DOID:2021 / placenta cancer [ cosmic ]
R1033 C1033 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1039 C1039 Biomuta DOID:1612 / breast cancer [ cosmic ]