Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y570 / PPME1_HUMAN
Protein Name Protein phosphatase methylesterase 1
Gene Name Name: PPME1
Synonyms:PME1;ORFNames:PP2593,PRO0750;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y570
DAG View
PRO Name protein phosphatase methylesterase 1 (human)
Definition A protein phosphatase methylesterase 1 that is encoded in the genome of human.
Short Label hPPME1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y570 (PPME1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Acetylation PhosphoSitePlus
K6 Ubiquitination PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
S15 Phosphorylation O14757 (CHEK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 24841198, 17287340, ...21851590
R16 Methylation PhosphoSitePlus   UniProt 24129315
S22 Phosphorylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
K30 Acetylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus   UniProt 19690332, 24275569
K121 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
C238 S-Nitrosylation dbSNO 26338901
T242 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
C312 S-Nitrosylation dbSNO 19483679
K338 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation HPRD 17287340, 20068231
S22 Phosphorylation HPRD 20068231
S27 Phosphorylation HPRD 20068231
T242 Phosphorylation HPRD 18669648, 20068231
S243 Phosphorylation HPRD 19413330, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R16 L16 Biomuta DOID:3571 / liver cancer [ icgc ]
S42 P42 Biomuta DOID:9256 / colorectal cancer [ icgc ]
C238 S238 Biomuta DOID:1324 / lung cancer [ icgc ]
K270 N270 Biomuta DOID:11934 / head and neck cancer [ tcga ]
C312 Y312 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]