iPTMnet Report for Q9Y4W2 (LAS1L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y4W2 / LAS1L_HUMAN
Protein Name Ribosomal biogenesis protein LAS1L
Gene Name Name: LAS1L
ORFNames:MSTP060;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y4W2
DAG View
PRO Name ribosomal biogenesis protein LAS1L (human)
Definition A LAS1-like protein that is encoded in the genome of human.
Short Label hLAS1L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y4W2 (LAS1L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation PhosphoSitePlus
Y24 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
C60 Methylation IEDB 31844290
K64 Ubiquitination PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
C97 Methylation IEDB 31844290
K98 Ubiquitination PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
S127 O-Glycosylation GlyGen 23301498, 30379171, 32522876, ...35083852, 28510447
S127 Phosphorylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K139 Methylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
C140 Methylation IEDB 31844290
K161 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K226 Sumoylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K295 Sumoylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus   UniProt 23186163
S477 Phosphorylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S523 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 16964243
S528 Phosphorylation PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
Y536 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
K565 Sumoylation PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus
S612 Phosphorylation PhosphoSitePlus
T613 Phosphorylation PhosphoSitePlus
S617 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...24275569, 19690332, 20068231
T619 Phosphorylation PhosphoSitePlus
K691 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S90 Phosphorylation HPRD 20068231
T91 Phosphorylation HPRD 20068231
S127 Phosphorylation HPRD 20068231
S404 Phosphorylation HPRD 20068231
S412 Phosphorylation HPRD 20068231
S523 Phosphorylation HPRD 18691976, 19007248, 19664995, ...20068231, 16964243
S560 Phosphorylation HPRD 19413330, 19651622, 20166139, ...20068231, 19007248
S617 Phosphorylation HPRD 19664995, 19664994, 19691289, ...18452278, 19651622, 20068231
T619 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K98 E98 Biomuta DOID:363 / uterine cancer [ icgc ]
K162 T162 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K215 N215 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S238 L238 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S246 G246 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S412 R412 Biomuta DOID:363 / uterine cancer [ icgc ]
K432 N432 Biomuta DOID:363 / uterine cancer [ icgc ]
S523 P523 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K551 N551 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T613 R613 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T613 I613 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]