Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9Y4R8 / TELO2_HUMAN
Protein Name Telomere length regulation protein TEL2 homolog
Gene Name Name: TELO2
Organism Homo sapiens (Human)

DAG View
PRO Name telomere length regulation protein TEL2 homolog (human)
Definition A telomere length regulation protein TEL2 that is encoded in the genome of human.
Short Label hTELO2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9Y4R8 (TELO2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K36 Ubiquitination PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
R250 Methylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K425 Sumoylation PhosphoSitePlus
S456 Phosphorylation HPRD 15345747
S485 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   UniProt 23263282
S487 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor   UniProt 23263282, 20864032
S491 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor   UniProt 23263282, 20864032
K510 Ubiquitination PhosphoSitePlus
Y543 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
T632 Phosphorylation PhosphoSitePlus
S637 Phosphorylation HPRD   PhosphoSitePlus 18691976
T642 Phosphorylation HPRD   PhosphoSitePlus 19413330
S688 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 20068231
S694 Phosphorylation PhosphoSitePlus
S799 Phosphorylation PhosphoSitePlus
K807 Ubiquitination PhosphoSitePlus
S836 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...18691976, 19651622, 18669648, 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K362 E362 Biomuta DOID:363 / uterine cancer [ tcga ]
S386 R386 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S456 C456 Biomuta DOID:1324 / lung cancer [ tcga ]
Y543 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T632 S632 Biomuta DOID:1909 / melanoma [ icgc, tcga ]