iPTMnet Report for Q9Y4P1 (ATG4B)
Protein Information
| UniProt AC / UniProt ID | Q9Y4P1 / ATG4B_HUMAN |
| Protein Name | Cysteine protease ATG4B |
| Gene Name | Name: ATG4B Synonyms:APG4B; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9Y4P1 |
| PRO Name | cysteine protease ATG4B (human) |
| Definition | A cysteine protease ATG4B that is encoded in the genome of human. |
| Short Label | hATG4B |
| Category | organism-gene |
DAG ViewQ9Y4P1 (ATG4B) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 19413330, 22814378, 22223895 | ||
| T5 | O-Glycosylation | score2 | GlyGen | 27527864 | ||
| Y8 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T10 | O-Glycosylation | score2 | GlyGen | 27527864 | ||
| S23 | O-Glycosylation | score2 | GlyGen | 27527864 | ||
| S34 | O-Glycosylation | score2 | GlyGen | 27527864 | ||
| S34 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 33607258, 29165041, 30443548 | ||
| T37 | O-Glycosylation | score2 | GlyGen | 27527864 | ||
| K39 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S44 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S68 | O-Glycosylation | score2 | GlyGen | 27527864 | ||
| T70 | O-Glycosylation | score2 | GlyGen | 27527864 | ||
| K102 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S110 | O-Glycosylation | score2 | GlyGen | 27527864 | ||
| K119 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S121 | Phosphorylation | score0 | RLIMS-P | 30443548 | ||
| Y122 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y123 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S138 | O-Glycosylation | score2 | GlyGen | 27527864 | ||
| K153 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S262 | Phosphorylation | score0 | RLIMS-P | 30443548 | ||
| S316 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P UniProt | 28821708 | ||
| K337 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S383 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 19369195, 21406692, 17081983, ... | ||
| S392 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 26378241, 17081983 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S383 | Phosphorylation | score0 | HPRD | 17322306, 19651622, 19664994, ... | ||
| S392 | Phosphorylation | score0 | HPRD | 19651622, 17081983 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S69 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q9Y4P1 (ATG4B) | S316 | Q9H492 (MAP1LC3A) | decreased_association | eFIP | 28821708 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y8 | C8 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
| S34 | I34 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S44 | Y44 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S44 | F44 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| Y122 | C122 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] |
