Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y4L1 / HYOU1_HUMAN
Protein Name Hypoxia up-regulated protein 1 precursor
Gene Name Name: HYOU1
Synonyms:GRP170,ORP150;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y4L1
DAG View
PRO Name hypoxia up-regulated protein 1 (human)
Definition A hypoxia up-regulated protein 1 that is encoded in the genome of human.
Short Label hHYOU1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y4L1 (HYOU1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K51 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
R79 Methylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
Y116 Phosphorylation PhosphoSitePlus
N155 N-Glycosylation UniProt 12754519
K198 Acetylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
Y213 Phosphorylation PhosphoSitePlus
R262 Methylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
R278 Methylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
Y421 Phosphorylation PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
Y443 Phosphorylation PhosphoSitePlus
K463 Acetylation PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
N515 N-Glycosylation UniProt 16263699, 16335952, 12754519, ...19159218, 19349973
K522 Ubiquitination PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
K530 Acetylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus   UniProt 24275569
T580 O-Glycosylation PhosphoSitePlus
T589 O-Glycosylation PhosphoSitePlus
T590 O-Glycosylation PhosphoSitePlus
T590 Phosphorylation PhosphoSitePlus
N596 N-Glycosylation UniProt 12754519, 19159218
T600 Phosphorylation PhosphoSitePlus
S634 Phosphorylation PhosphoSitePlus
K685 Acetylation PhosphoSitePlus
T727 Phosphorylation PhosphoSitePlus
K738 Ubiquitination PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus
K753 Ubiquitination PhosphoSitePlus
Y759 Phosphorylation PhosphoSitePlus
S763 Phosphorylation PhosphoSitePlus
K797 Acetylation PhosphoSitePlus
N830 N-Glycosylation UniProt 16335952, 12754519, 19159218
T850 Phosphorylation PhosphoSitePlus
N862 N-Glycosylation UniProt 12754519, 19159218
N869 N-Glycosylation UniProt 16335952
R900 Methylation PhosphoSitePlus
Y904 Phosphorylation PhosphoSitePlus
N931 N-Glycosylation UniProt 16335952, 12754519, 19159218
T948 Phosphorylation PhosphoSitePlus
S955 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T727 Phosphorylation HPRD 20068231
Y759 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T269 A269 Biomuta DOID:363 / uterine cancer [ tcga ]
R278 W278 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R278 L278 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
S527 R527 Biomuta DOID:3571 / liver cancer [ icgc ]
K537 N537 Biomuta DOID:363 / uterine cancer [ tcga ]
T589 I589 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
N596 S596 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
N830 K830 Biomuta DOID:3571 / liver cancer [ icgc ]