iPTMnet Report for Q9Y4H2 (IRS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y4H2 / IRS2_HUMAN
Protein Name Insulin receptor substrate 2
Gene Name Name: IRS2
Organism Homo sapiens (Human)

PRO ID PR:Q9Y4H2
DAG View
PRO Name insulin receptor substrate 2 (human)
Definition An insulin receptor substrate 2 that is encoded in the genome of human.
Short Label hIRS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y4H2 (IRS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
S3 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
Y75 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18083107, 25580119
Y76 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
Y111 Phosphorylation PhosphoSitePlus
Y184 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119
K295 Ubiquitination PhosphoSitePlus
S304 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 25580119, 12351658
K305 Ubiquitination PhosphoSitePlus
S306 Phosphorylation P05771 (PRKCB) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23775122, 21406692, 12351658, ...23186163, 18077418, 19651622, 18669648, 25580119, 20068231
S308 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648
S309 Phosphorylation HPRD   PhosphoSitePlus 17081983
S311 Phosphorylation PhosphoSitePlus
S312 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119
T314 Phosphorylation PhosphoSitePlus
S334 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 17525332, 25580119
S342 Phosphorylation HPRD   PhosphoSitePlus 20068231
T344 Phosphorylation PhosphoSitePlus
S346 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 25580119, 16964243
T350 Phosphorylation P45983 (MAPK8) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 16964243, 18669648, ...25580119, 17050683, 20068231
S358 Phosphorylation HPRD   PhosphoSitePlus 20068231
T363 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 19664994, 18669648, 25580119, ...19415658, 20068231
S365 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18491316, 18220336, 18669648, ...25580119, 20068231
S384 O-Glycosylation GlyGen 31373491
S384 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 12351658, 19651622, 18669648, ...25580119, 20068231
S388 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 12351658, 18088087, 17081983, ...18220336, 26657864, 19651622, 18669648, 25580119, 19415658, 20068231
S391 O-Glycosylation GlyGen 23301498, 30059200, 35254053, ...31373491, 32798372, 36240223, 35289036
S391 Phosphorylation P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19369195, 18491316, 18088087, ...17081983, 18220336, 18234856, 19651622, 18669648, 25580119, 20068231
S400 Phosphorylation PhosphoSitePlus
T404 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
R412 Methylation PhosphoSitePlus   UniProt 24129315
S428 O-Glycosylation GlyGen 23301498, 30059200, 35254053, ...31373491, 32798372, 36240223, 35289036
R429 Methylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
S491 Phosphorylation P45983 (MAPK8) neXtProt 18029441
S505 Phosphorylation PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
S518 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119
T520 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18669648, 25580119, ...15302935
S523 O-Glycosylation GlyGen 31373491
S523 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 25580119
T527 O-Glycosylation GlyGen 23301498, 30059200, 35254053, ...31373491, 32798372, 36240223, 35289036
T527 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 16964243, 19664994, ...17322306, 18669648, 25580119
Y540 Phosphorylation PhosphoSitePlus
Y542 Phosphorylation PhosphoSitePlus
T544 Phosphorylation PhosphoSitePlus
S550 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119
S560 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...19651622, 18669648, 25580119, 19415658, 20068231
R569 Methylation PhosphoSitePlus
T575 Phosphorylation PhosphoSitePlus
Y576 Phosphorylation PhosphoSitePlus
S577 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 12351658, 23186163, 16964243, ...18220336, 18767875, 19664994, 18669648, 25580119, 20068231
T579 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T580 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243
S591 Phosphorylation PhosphoSitePlus
S592 Phosphorylation HPRD   PhosphoSitePlus 17081983
S594 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 17081983, 19651622, ...18669648, 25580119, 24275569, 20068231
Y598 Phosphorylation PhosphoSitePlus
T599 Phosphorylation PhosphoSitePlus
T604 Phosphorylation HPRD   PhosphoSitePlus 20166139
S606 Phosphorylation HPRD   PhosphoSitePlus 20166139
S608 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18088087, 18669648, 25580119, ...20166139, 20068231
S615 Phosphorylation PhosphoSitePlus
S619 Phosphorylation HPRD   PhosphoSitePlus 20068231
S620 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 25580119, 19664995
Y625 Phosphorylation PhosphoSitePlus
Y628 Phosphorylation P06213 (INSR) HPRD   PhosphoSitePlus 9195949
Y632 Phosphorylation P06213 (INSR) HPRD   PhosphoSitePlus 19901323, 9195949
S639 Phosphorylation PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
Y653 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18083107, 25580119, 16497976
T657 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 22028470
S665 Phosphorylation PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus
S672 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y675 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18083107, 18669648, ...25580119, 20068231, 16497976
S679 Phosphorylation P05771 (PRKCB) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23775122, 18669648, 25580119, ...23186163
S682 Phosphorylation PhosphoSitePlus   UniProt 23186163
S704 O-Glycosylation GlyGen 23301498, 30059200, 35254053, ...31373491, 32798372, 36240223, 35289036
T713 O-Glycosylation GlyGen 31373491
T713 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119, 18220336
S714 O-Glycosylation GlyGen 23301498, 30059200, 35254053, ...31373491, 32798372, 36240223, 35289036
S714 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119, 20068231
S723 Phosphorylation PhosphoSitePlus
S730 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 19413330, 17081983, 18669648, ...25580119, 20068231
S731 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 28065675, 17081983, 20685959, ...19651622, 18669648, 25580119, 20068231
S735 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19651622, 18669648, 25580119, ...20068231
S736 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 17322306, 23186163, ...18767875, 19651622, 18669648, 25580119, 19415658, 20068231
S740 Phosphorylation PhosphoSitePlus
Y742 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
S752 Phosphorylation PhosphoSitePlus
Y766 Phosphorylation PhosphoSitePlus
S770 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 25580119, 20068231, ...18220336
S772 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119, 18220336
T776 Phosphorylation PhosphoSitePlus
T777 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119
T779 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 25580119, 20068231
Y803 Phosphorylation PhosphoSitePlus
S804 Phosphorylation PhosphoSitePlus
S805 Phosphorylation PhosphoSitePlus   UniProt 23186163
S809 Phosphorylation PhosphoSitePlus
Y810 Phosphorylation HPRD 16497976
Y814 Phosphorylation HPRD   PhosphoSitePlus 16497976
T815 Phosphorylation PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus
Y823 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18083107, 25580119, 19901323, ...16497976
S827 Phosphorylation PhosphoSitePlus
S828 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 25580119
T891 Phosphorylation PhosphoSitePlus
S894 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119
S903 Phosphorylation PhosphoSitePlus
S915 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 18088087, 18220336, ...19664994, 15302935, 19651622, 18669648, 25580119, 24275569, 23186163, 20068231
Y919 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119
S932 Phosphorylation PhosphoSitePlus
S973 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 17081983, 18452278, ...19651622, 18669648, 25580119, 24275569, 20068231
S976 Phosphorylation HPRD   PhosphoSitePlus 19651622
Y978 Phosphorylation HPRD   PhosphoSitePlus 17081983
S985 Phosphorylation HPRD 19651622
T1082 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1100 Phosphorylation HPRD   IEDB   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 32897882, 18088087, 16964243, ...15302935, 33936100, 18669648, 25580119, 27869121, 24275569, 11120772, 25297629, 23186163, 35260532, 32387766, 31848261, 20068231
S1103 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119
S1109 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119
S1124 O-Glycosylation GlyGen 31373491
K1134 Methylation PhosphoSitePlus
S1148 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119, 20068231
S1149 O-Glycosylation GlyGen 23301498, 30059200, 35254053, ...31373491, 32798372, 36240223, 35289036
S1149 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119, 15364919, ...20068231
T1151 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119
S1153 Phosphorylation HPRD 20068231
S1154 Phosphorylation PhosphoSitePlus
T1155 O-Glycosylation GlyGen 23301498, 30059200, 35254053, ...31373491, 32798372, 36240223, 35289036
T1156 Phosphorylation PhosphoSitePlus
T1157 Phosphorylation PhosphoSitePlus
T1159 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 25580119, 20068231
S1162 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19651622, 18669648, 25580119, ...20068231
S1164 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
K1170 Methylation PhosphoSitePlus
S1174 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 17081983, 18767875, ...18669648, 25580119, 20068231
S1176 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19651622, 21406692, 23186163, ...18220336, 17322306, 18669648, 25580119, 20068231
S1181 Phosphorylation PhosphoSitePlus
S1185 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1186 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163
T1202 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119, 18491316
S1203 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18491316, 23186163, 19664994, ...15302935, 18669648, 25580119, 19415658, 20068231
T1221 Phosphorylation PhosphoSitePlus
S1234 Phosphorylation PhosphoSitePlus
S1237 Phosphorylation PhosphoSitePlus
T1243 Phosphorylation PhosphoSitePlus
Y1253 Phosphorylation PhosphoSitePlus
S1283 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 25580119
Y1320 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048053 (hIRS2/PhosTyr+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S30 G30 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S304 R304 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S308 L308 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S309 W309 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S342 W342 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S342 L342 Biomuta DOID:1612 / breast cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
S432 F432 Biomuta [ cosmic ]
S491 C491 Biomuta DOID:1324 / lung cancer [ cosmic ]
S523 P523 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S550 N550 Biomuta DOID:1319 / brain cancer [ cosmic ]
R569 G569 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S577 F577 Biomuta DOID:4159 / skin cancer [ cosmic ]
T579 I579 Biomuta DOID:4159 / skin cancer [ icgc ]
T580 M580 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S591 F591 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S591 P591 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S592 P592 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S594 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S594 L594 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S619 F619 Biomuta DOID:363 / uterine cancer [ icgc ]
T657 M657 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S682 N682 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S704 F704 Biomuta DOID:1612 / breast cancer [ cosmic ]
S730 R730 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y742 H742 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S770 P770 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S804 I804 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S805 C805 Biomuta DOID:1324 / lung cancer [ cosmic ]
S820 N820 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y823 F823 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S828 Y828 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T891 P891 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S894 F894 Biomuta [ cosmic ]
S932 L932 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S973 F973 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T1082 P1082 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1153 F1153 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1154 F1154 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1156 M1156 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1162 F1162 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1162 P1162 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1174 L1174 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1176 F1176 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1181 F1181 Biomuta DOID:10534 / stomach cancer [ icgc ]
S1234 I1234 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1234 N1234 Biomuta DOID:9256 / colorectal cancer [ cosmic ]