iPTMnet Report for Q9Y4G8 (RAPGEF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y4G8 / RPGF2_HUMAN
Protein Name Rap guanine nucleotide exchange factor 2
Gene Name Name: RAPGEF2
Synonyms:KIAA0313,NRAPGEP,PDZGEF1;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y4G8
DAG View
PRO Name Rap guanine nucleotide exchange factor 2 (human)
Definition A Rap guanine nucleotide exchange factor 2 that is encoded in the genome of human.
Short Label hRAPGEF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y4G8 (RAPGEF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S85 Phosphorylation PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
T293 Phosphorylation PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
T387 Phosphorylation HPRD   PhosphoSitePlus 20068231
S498 Phosphorylation PhosphoSitePlus
Y500 Phosphorylation PhosphoSitePlus
S501 Phosphorylation PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
S583 Phosphorylation HPRD   PhosphoSitePlus 20068231
S584 Phosphorylation HPRD   PhosphoSitePlus 17081983
S585 Phosphorylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
T602 Phosphorylation PhosphoSitePlus
S619 Phosphorylation PhosphoSitePlus
Y621 Phosphorylation PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
K688 Ubiquitination PhosphoSitePlus
K789 Ubiquitination PhosphoSitePlus
T824 O-Glycosylation GlyGen 35254053, 30059200, 29351928, ...31492838, 30620550, 28657654, 29237092
T825 O-Glycosylation GlyGen 35254053, 30059200, 29351928, ...31492838, 30620550, 28657654, 29237092
Y853 Phosphorylation PhosphoSitePlus
S859 Phosphorylation PhosphoSitePlus
K875 Ubiquitination PhosphoSitePlus
K896 Ubiquitination PhosphoSitePlus
S912 Phosphorylation PhosphoSitePlus
S930 Phosphorylation PhosphoSitePlus
S935 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17525332, 18669648
S959 Phosphorylation HPRD   PhosphoSitePlus 20068231
S960 Phosphorylation Q04759 (PRKCQ) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor 19651622, 18796635, 20068231
Y968 Phosphorylation PhosphoSitePlus
K976 Ubiquitination PhosphoSitePlus
T1006 Phosphorylation PhosphoSitePlus
S1022 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 18088087
S1080 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1089 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S1095 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1116 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18088087
T1119 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18088087
S1120 Phosphorylation PhosphoSitePlus
S1124 Phosphorylation PhosphoSitePlus   RLIMS-P 25189171
S1156 Phosphorylation PhosphoSitePlus
S1159 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1166 O-Glycosylation GlyGen 35254053, 30059200, 29351928, ...31492838, 30620550, 28657654, 29237092
S1176 Phosphorylation PhosphoSitePlus
S1178 Phosphorylation PhosphoSitePlus
T1193 Phosphorylation PhosphoSitePlus
Y1200 Phosphorylation PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
S1244 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus 24290981
S1248 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus 24290981
S1254 Phosphorylation O14920 (IKBKB) PhosphoSitePlus 24290981
S1256 Phosphorylation PhosphoSitePlus
S1316 Phosphorylation PhosphoSitePlus
S1325 Phosphorylation PhosphoSitePlus
S1337 Phosphorylation PhosphoSitePlus
T1341 Phosphorylation PhosphoSitePlus
T1343 Phosphorylation PhosphoSitePlus
S1487 Phosphorylation PhosphoSitePlus
T1488 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T275 N275 Biomuta DOID:1324 / lung cancer [ cosmic ]
S288 * Biomuta DOID:3571 / liver cancer [ cosmic ]
T387 M387 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S501 P501 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S501 F501 Biomuta DOID:4159 / skin cancer [ cosmic ]
S585 G585 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S592 T592 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S592 L592 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S859 R859 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S959 C959 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
K976 E976 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S1080 Y1080 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1124 Y1124 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
S1159 P1159 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1166 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S1223 C1223 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1244 I1244 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1337 * Biomuta DOID:4159 / skin cancer [ cosmic ]