iPTMnet Report for Q9Y4G6 (TLN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y4G6 / TLN2_HUMAN
Protein Name Talin-2
Gene Name Name: TLN2
Synonyms:KIAA0320;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y4G6
DAG View
PRO Name talin-2 (human)
Definition A talin-2 that is encoded in the genome of human.
Short Label hTLN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y4G6 (TLN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K17 Ubiquitination PhosphoSitePlus
Y28 Phosphorylation PhosphoSitePlus
Y49 Phosphorylation PhosphoSitePlus
T69 Phosphorylation PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
S179 Phosphorylation HPRD 20068231
Y201 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
T310 Phosphorylation PhosphoSitePlus
Y311 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus
S428 Phosphorylation HPRD   PhosphoSitePlus 19664994
S449 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
S473 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S521 Phosphorylation PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
T632 Phosphorylation PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus
T639 Phosphorylation HPRD   PhosphoSitePlus 20068231
S646 Phosphorylation PhosphoSitePlus
S651 Phosphorylation HPRD 20068231
S673 Phosphorylation PhosphoSitePlus
K690 Ubiquitination PhosphoSitePlus
S845 Phosphorylation PhosphoSitePlus
K878 Ubiquitination PhosphoSitePlus
S1000 Phosphorylation PhosphoSitePlus
S1004 Phosphorylation PhosphoSitePlus
S1005 Phosphorylation PhosphoSitePlus
S1023 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y1118 Phosphorylation PhosphoSitePlus
S1266 Phosphorylation PhosphoSitePlus
S1277 Phosphorylation PhosphoSitePlus
T1296 Phosphorylation PhosphoSitePlus
K1322 Ubiquitination PhosphoSitePlus
S1325 Phosphorylation PhosphoSitePlus
S1408 Phosphorylation PhosphoSitePlus
K1543 Acetylation PhosphoSitePlus
K1543 Ubiquitination PhosphoSitePlus
S1621 O-Glycosylation GlyGen 30379171, 31637018
S1643 Phosphorylation PhosphoSitePlus
Y1665 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
S1666 Phosphorylation PhosphoSitePlus
T1793 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1838 Acetylation PhosphoSitePlus
T1843 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...16964243, 15302935, 19664994, 19651622, 18669648, 24275569, 20068231, 17081983
Y1854 Phosphorylation PhosphoSitePlus
T1856 Phosphorylation PhosphoSitePlus
T2031 O-Glycosylation GlyGen 30379171, 31637018
S2036 O-Glycosylation GlyGen 30379171, 31637018
T2041 Phosphorylation PhosphoSitePlus
T2077 Phosphorylation PhosphoSitePlus
T2124 Phosphorylation PhosphoSitePlus
S2128 Phosphorylation PhosphoSitePlus
K2181 Ubiquitination PhosphoSitePlus
T2184 Phosphorylation PhosphoSitePlus
T2187 Phosphorylation PhosphoSitePlus
R2198 Methylation PhosphoSitePlus
S2214 Phosphorylation PhosphoSitePlus
T2218 Phosphorylation PhosphoSitePlus
T2282 Phosphorylation PhosphoSitePlus
S2352 Phosphorylation PhosphoSitePlus
S2427 Phosphorylation PhosphoSitePlus
S2428 Phosphorylation PhosphoSitePlus
K2477 Acetylation PhosphoSitePlus
K2477 Methylation PhosphoSitePlus
K2482 Methylation PhosphoSitePlus
Y2530 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K17 Q17 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y28 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y72 H72 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y72 C72 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T146 K146 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S426 F426 Biomuta DOID:4159 / skin cancer [ cosmic ]
S428 F428 Biomuta DOID:4159 / skin cancer [ cosmic ]
S449 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
S460 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S521 P521 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S651 N651 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K878 N878 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1266 R1266 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1296 A1296 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1325 F1325 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1838 M1838 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1856 M1856 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S2128 L2128 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T2218 M2218 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S2427 L2427 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]