iPTMnet Report for Q9Y4E8 (USP15)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y4E8 / UBP15_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 15
Gene Name Name: USP15
Synonyms:KIAA0529;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y4E8
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 15 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 15 that is encoded in the genome of human.
Short Label hUSP15
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y4E8 (USP15) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
K21 Ubiquitination PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
Y89 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
T149 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
T226 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K228 Ubiquitination PhosphoSitePlus
S229 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 16964243, ...29429988, 18669648, 19690332, 20068231
S233 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S244 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K259 Methylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
Y263 Phosphorylation PhosphoSitePlus
Y268 Phosphorylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
Y271 Phosphorylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus
Y276 Phosphorylation PhosphoSitePlus
C306 Methylation IEDB 31844290
K340 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K363 Methylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
T602 Phosphorylation PhosphoSitePlus
K605 Ubiquitination PhosphoSitePlus
Y607 Phosphorylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus 17478428
S678 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
Y726 Phosphorylation PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
K758 Acetylation PhosphoSitePlus
K758 Ubiquitination PhosphoSitePlus
K759 Acetylation PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
K789 Ubiquitination PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
K813 Ubiquitination PhosphoSitePlus
S826 Phosphorylation PhosphoSitePlus
Y875 Phosphorylation PhosphoSitePlus
S881 Phosphorylation PhosphoSitePlus
Y926 Phosphorylation PhosphoSitePlus
S961 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S965 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S102 Phosphorylation HPRD 20068231
Y104 Phosphorylation HPRD 20068231
T226 Phosphorylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
Y234 Phosphorylation PhosphoSitePlus
Y245 Phosphorylation PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus
T573 Phosphorylation HPRD 20068231
Y578 Phosphorylation HPRD 20068231
S923 Phosphorylation HPRD 20068231
T926 Phosphorylation HPRD 20068231
S932 Phosphorylation HPRD 19413330, 18669648, 20068231
S936 Phosphorylation HPRD 19413330, 18669648, 19415658, ...20068231
T951 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S225 Phosphorylation PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y89 C89 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
K163 N163 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T219 A219 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T219 I219 Biomuta DOID:3571 / liver cancer [ cosmic ]
S229 F229 Biomuta DOID:4159 / skin cancer [ cosmic ]
S244 L244 Biomuta DOID:1324 / lung cancer [ cosmic ]
S261 P261 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T269 A269 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
C306 F306 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K402 N402 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K416 E416 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S678 R678 Biomuta DOID:3571 / liver cancer [ cosmic ]
K759 I759 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
Y875 C875 Biomuta DOID:3571 / liver cancer [ cosmic ]
S881 F881 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T951 S951 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]