iPTMnet Report for Q9Y4E5 (ZNF451)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y4E5 / ZN451_HUMAN
Protein Name E3 SUMO-protein ligase ZNF451
Gene Name Name: ZNF451
Synonyms:COASTER;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y4E5
DAG View
PRO Name E3 SUMO-protein ligase ZNF451 (human)
Definition An E3 SUMO-protein ligase ZNF451 that is encoded in the genome of human.
Short Label hZNF451
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y4E5 (ZNF451) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S50 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K75 Sumoylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K77 Sumoylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K106 Sumoylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
T127 Phosphorylation PhosphoSitePlus
K139 Sumoylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K144 Sumoylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K153 Sumoylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus   UniProt 23186163
R158 Methylation PhosphoSitePlus   UniProt 24129315
K167 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
C198 Methylation IEDB 31844290
K220 Sumoylation PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
K275 Acetylation PhosphoSitePlus
K275 Sumoylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K283 Acetylation PhosphoSitePlus
K283 Sumoylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K288 Sumoylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K302 Sumoylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K316 Sumoylation PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
K357 Sumoylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
K423 Sumoylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K428 Sumoylation PhosphoSitePlus
T430 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus   UniProt 23186163
K434 Sumoylation PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
C441 Methylation IEDB 31844290
K446 Sumoylation PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K452 Sumoylation PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
K454 Sumoylation PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
K464 Sumoylation PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K499 Sumoylation PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
K543 Sumoylation PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
K605 Sumoylation PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
K632 Sumoylation PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
K647 Sumoylation PhosphoSitePlus
K664 Sumoylation PhosphoSitePlus
K664 Ubiquitination PhosphoSitePlus
K706 Sumoylation PhosphoSitePlus
K706 Ubiquitination PhosphoSitePlus
C730 Methylation IEDB 31844290
K731 Sumoylation PhosphoSitePlus
K731 Ubiquitination PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus
K750 Sumoylation PhosphoSitePlus
K750 Ubiquitination PhosphoSitePlus
K779 Sumoylation PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
K790 Sumoylation PhosphoSitePlus
K790 Ubiquitination PhosphoSitePlus
C791 Methylation IEDB 31844290
K796 Ubiquitination PhosphoSitePlus
K811 Sumoylation PhosphoSitePlus
K811 Ubiquitination PhosphoSitePlus
K817 Sumoylation PhosphoSitePlus
K817 Ubiquitination PhosphoSitePlus
S825 Phosphorylation PhosphoSitePlus
K827 Sumoylation PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
Y831 Phosphorylation PhosphoSitePlus
K832 Sumoylation PhosphoSitePlus
K832 Ubiquitination PhosphoSitePlus
S838 Phosphorylation PhosphoSitePlus
T840 Phosphorylation PhosphoSitePlus
K843 Sumoylation PhosphoSitePlus
K843 Ubiquitination PhosphoSitePlus
K845 Sumoylation PhosphoSitePlus
K845 Ubiquitination PhosphoSitePlus
K852 Sumoylation PhosphoSitePlus
K852 Ubiquitination PhosphoSitePlus
S853 Phosphorylation PhosphoSitePlus
K858 Ubiquitination PhosphoSitePlus
K951 Ubiquitination PhosphoSitePlus
K971 Ubiquitination PhosphoSitePlus
K992 Sumoylation PhosphoSitePlus
K992 Ubiquitination PhosphoSitePlus
K993 Ubiquitination PhosphoSitePlus
K1023 Ubiquitination PhosphoSitePlus
S1027 Phosphorylation PhosphoSitePlus
K1034 Ubiquitination PhosphoSitePlus
S1037 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S108 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K130 Sumoylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K138 Sumoylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K164 Sumoylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K247 Sumoylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K263 Sumoylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
K286 Sumoylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus
K490 Sumoylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
K500 Sumoylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
K508 Sumoylation PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
K522 Sumoylation PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
R528 Methylation PhosphoSitePlus
K532 Sumoylation PhosphoSitePlus
K532 Ubiquitination PhosphoSitePlus
K537 Sumoylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
Y557 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S108 Y108 Biomuta DOID:363 / uterine cancer [ icgc ]
S155 L155 Biomuta DOID:4159 / skin cancer [ cosmic ]
K220 T220 Biomuta DOID:363 / uterine cancer [ icgc ]
K301 N301 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K316 R316 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K349 N349 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K428 E428 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S432 Y432 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S432 C432 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K454 E454 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K454 R454 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K470 N470 Biomuta DOID:1324 / lung cancer [ cosmic ]
K532 N532 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K537 I537 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S551 C551 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S601 Y601 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
Y831 C831 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S838 L838 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K843 N843 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K852 T852 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K971 R971 Biomuta DOID:363 / uterine cancer [ icgc ]
K992 N992 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1037 T1037 Biomuta DOID:3571 / liver cancer [ cosmic ]