iPTMnet Report for Q9Y4C1 (KDM3A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y4C1 / KDM3A_HUMAN
Protein Name Lysine-specific demethylase 3A
Gene Name Name: KDM3A
Synonyms:JHDM2A,JMJD1,JMJD1A,KIAA0742,TSGA;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y4C1
DAG View
PRO Name lysine-specific demethylase 3A (human)
Definition A lysine-specific demethylase 3A that is encoded in the genome of human.
Short Label hKDM3A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y4C1 (KDM3A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation RLIMS-P 23593242
S71 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
T129 Phosphorylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
S264 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 25535969, 20068231, ...25948511
S265 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   RLIMS-P 29674659, 35108679, 25948511
S283 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
T308 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T319 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus   UniProt 23186163
C349 Methylation IEDB 31844290
K353 Ubiquitination PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
K371 Acetylation PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
K381 Acetylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
K421 Acetylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
S445 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 20068231
S463 Phosphorylation HPRD   PhosphoSitePlus 15302935
K470 Acetylation PhosphoSitePlus
S481 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S495 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
K558 Acetylation PhosphoSitePlus
Y620 Phosphorylation PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
T642 Phosphorylation PhosphoSitePlus
K691 Ubiquitination PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
T723 Phosphorylation PhosphoSitePlus
K729 Ubiquitination PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus
K763 Ubiquitination PhosphoSitePlus
S766 Phosphorylation PhosphoSitePlus   UniProt 23186163
K779 Ubiquitination PhosphoSitePlus
S819 Phosphorylation PhosphoSitePlus
K839 Methylation PhosphoSitePlus
K839 Ubiquitination PhosphoSitePlus
T842 Phosphorylation PhosphoSitePlus
K847 Ubiquitination PhosphoSitePlus
K851 Ubiquitination PhosphoSitePlus
K895 Acetylation PhosphoSitePlus   UniProt 19608861
K895 Ubiquitination PhosphoSitePlus
K901 Ubiquitination PhosphoSitePlus
K905 Ubiquitination PhosphoSitePlus
K918 Acetylation PhosphoSitePlus
K918 Ubiquitination PhosphoSitePlus
K925 Ubiquitination PhosphoSitePlus
K960 Ubiquitination PhosphoSitePlus
K971 Ubiquitination PhosphoSitePlus
K984 Ubiquitination PhosphoSitePlus
K997 Ubiquitination PhosphoSitePlus
K1046 Ubiquitination PhosphoSitePlus
K1080 Ubiquitination PhosphoSitePlus
Y1090 Phosphorylation PhosphoSitePlus
Y1101 Phosphorylation PhosphoSitePlus   RLIMS-P 23593242
Y1104 Phosphorylation PhosphoSitePlus
Y1114 Phosphorylation Q07912 (TNK2) PhosphoSitePlus 25148682
S1124 Phosphorylation PhosphoSitePlus
K1148 Ubiquitination PhosphoSitePlus
S1155 Phosphorylation PhosphoSitePlus
K1161 Ubiquitination PhosphoSitePlus
K1190 Ubiquitination PhosphoSitePlus
S1266 Phosphorylation PhosphoSitePlus
K1271 Ubiquitination PhosphoSitePlus
K1297 Ubiquitination PhosphoSitePlus
Y1301 Phosphorylation PhosphoSitePlus
K1320 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9Y4C1 (KDM3A) S264 P42224 (STAT1) unknown eFIP 25535969


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S127 F127 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T129 I129 Biomuta DOID:1612 / breast cancer [ cosmic ]
K144 E144 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K144 I144 Biomuta DOID:3571 / liver cancer [ cosmic ]
T319 I319 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S325 F325 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
C349 S349 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S370 L370 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K381 R381 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K421 N421 Biomuta DOID:1324 / lung cancer [ cosmic ]
S445 F445 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S445 P445 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S641 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S641 P641 Biomuta DOID:363 / uterine cancer [ icgc ]
K748 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K763 R763 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T842 P842 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K847 N847 Biomuta DOID:363 / uterine cancer [ icgc ]
K901 N901 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K984 T984 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1124 C1124 Biomuta [ cosmic ] DOID:1612 / breast cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
S1155 P1155 Biomuta DOID:363 / uterine cancer [ icgc ]