iPTMnet Report for Q9Y4B5 (MTCL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y4B5 / MTCL1_HUMAN
Protein Name Microtubule cross-linking factor 1
Gene Name Name: MTCL1
Synonyms:CCDC165,KIAA0802,SOGA2;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y4B5
DAG View
PRO Name microtubule cross-linking factor 1 (human)
Definition A microtubule cross-linking factor 1 that is encoded in the genome of human.
Short Label hMTCL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y4B5 (MTCL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S87 Phosphorylation PhosphoSitePlus   UniProt 23186163
S98 Phosphorylation PhosphoSitePlus
S142 O-Glycosylation GlyGen 30379171, 28657654, 29351928, ...34019948, 35254053, 31373491
T187 O-Glycosylation GlyGen 30379171, 28657654, 29351928, ...34019948, 35254053, 31373491
S196 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
T206 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S306 Phosphorylation PhosphoSitePlus
T315 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus   UniProt 19369195, 18669648, 23186163, ...19690332
S618 Phosphorylation PhosphoSitePlus   UniProt 18669648
T621 Phosphorylation PhosphoSitePlus   UniProt 18669648
S622 Phosphorylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus
T663 O-Glycosylation GlyGen 30379171, 28657654, 29351928, ...34019948, 35254053, 31373491
S685 Phosphorylation PhosphoSitePlus   UniProt 20068231
K714 Ubiquitination PhosphoSitePlus
S741 Phosphorylation PhosphoSitePlus
S745 O-Glycosylation GlyGen 30379171, 28657654, 29351928, ...34019948, 35254053, 31373491
S745 Phosphorylation PhosphoSitePlus
S749 Phosphorylation PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus
S776 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S778 Phosphorylation PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus
S901 Phosphorylation PhosphoSitePlus   UniProt 18669648
T907 Phosphorylation PhosphoSitePlus
S914 Phosphorylation phospho.ELM 18669648
S923 Phosphorylation PhosphoSitePlus   UniProt 18669648
K930 Ubiquitination PhosphoSitePlus
S938 Phosphorylation PhosphoSitePlus
K941 Phosphorylation UniProt 18669648
K941 Ubiquitination PhosphoSitePlus
T975 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231
S977 Phosphorylation PhosphoSitePlus
T984 Phosphorylation PhosphoSitePlus
S987 Phosphorylation PhosphoSitePlus
K1001 Ubiquitination PhosphoSitePlus
S1007 Phosphorylation PhosphoSitePlus
T1018 Phosphorylation PhosphoSitePlus
S1020 Phosphorylation PhosphoSitePlus
K1023 Ubiquitination PhosphoSitePlus
K1055 Ubiquitination PhosphoSitePlus
S1106 Phosphorylation PhosphoSitePlus
S1117 Phosphorylation PhosphoSitePlus
K1130 Ubiquitination PhosphoSitePlus
K1195 Ubiquitination PhosphoSitePlus
K1206 Ubiquitination PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
K1245 Ubiquitination PhosphoSitePlus
K1275 Ubiquitination PhosphoSitePlus
S1278 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1284 Phosphorylation PhosphoSitePlus
K1290 Ubiquitination PhosphoSitePlus
S1302 Phosphorylation PhosphoSitePlus
R1304 Methylation PhosphoSitePlus
R1307 Methylation PhosphoSitePlus
S1319 Phosphorylation PhosphoSitePlus
S1328 Phosphorylation PhosphoSitePlus
K1329 Ubiquitination PhosphoSitePlus
K1377 Methylation PhosphoSitePlus
K1377 Ubiquitination PhosphoSitePlus
S1385 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S1387 Phosphorylation PhosphoSitePlus
S1388 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1399 Phosphorylation PhosphoSitePlus   UniProt 20068231
K1405 Ubiquitination PhosphoSitePlus
S1409 Phosphorylation PhosphoSitePlus
T1410 Phosphorylation PhosphoSitePlus
S1411 Phosphorylation PhosphoSitePlus
S1412 Phosphorylation phospho.ELM 18669648, 16565220, 17081983, ...16964243
T1417 Phosphorylation PhosphoSitePlus   UniProt 18669648, 16964243
S1421 Phosphorylation PhosphoSitePlus   UniProt 18669648, 16964243
Y1427 Phosphorylation PhosphoSitePlus   UniProt 18669648
K1433 Ubiquitination PhosphoSitePlus
S1434 Phosphorylation PhosphoSitePlus
T1438 Phosphorylation PhosphoSitePlus
S1507 Phosphorylation PhosphoSitePlus
S1514 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1523 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1525 Phosphorylation PhosphoSitePlus
R1539 Methylation PhosphoSitePlus
S1541 Phosphorylation PhosphoSitePlus
S1561 Phosphorylation PhosphoSitePlus   UniProt 18669648
Y1568 Phosphorylation PhosphoSitePlus
S1578 Phosphorylation PhosphoSitePlus   UniProt 18669648
T1582 Phosphorylation PhosphoSitePlus
S1583 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S1588 O-Glycosylation GlyGen 30379171, 28657654, 29351928, ...34019948, 35254053, 31373491
S1588 Phosphorylation PhosphoSitePlus
S1592 Phosphorylation PhosphoSitePlus   UniProt 18669648
K1597 Ubiquitination PhosphoSitePlus
S1600 Phosphorylation PhosphoSitePlus
K1604 Ubiquitination PhosphoSitePlus
S1609 Phosphorylation PhosphoSitePlus
S1616 Phosphorylation PhosphoSitePlus
S1656 Phosphorylation PhosphoSitePlus
S1661 Phosphorylation PhosphoSitePlus   UniProt 18669648
T1667 Phosphorylation PhosphoSitePlus   UniProt 18669648
T1675 Phosphorylation PhosphoSitePlus   UniProt 18669648, 16964243
S1678 Phosphorylation PhosphoSitePlus
S1679 Phosphorylation PhosphoSitePlus   UniProt 16964243
S1681 Phosphorylation PhosphoSitePlus
S1683 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1706 Phosphorylation PhosphoSitePlus
S1711 Phosphorylation PhosphoSitePlus
K1713 Ubiquitination PhosphoSitePlus
S1730 Phosphorylation PhosphoSitePlus
S1752 Phosphorylation PhosphoSitePlus
S1772 Phosphorylation PhosphoSitePlus
S1789 Phosphorylation PhosphoSitePlus
S1791 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1808 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1812 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1814 Phosphorylation PhosphoSitePlus   UniProt 18669648
S1820 Phosphorylation PhosphoSitePlus
T1831 Phosphorylation PhosphoSitePlus
S1838 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K210 Ubiquitination PhosphoSitePlus
T935 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S937 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S941 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S975 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S87 L87 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S253 N253 Biomuta DOID:4159 / skin cancer [ cosmic ]
S306 W306 Biomuta DOID:11054 / urinary bladder cancer [ icgc ]
S320 G320 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T621 N621 Biomuta DOID:4159 / skin cancer [ cosmic ]
S627 F627 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T663 I663 Biomuta DOID:3571 / liver cancer [ cosmic ]
T663 A663 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S685 N685 Biomuta [ cosmic ]
S790 R790 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S901 F901 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1007 G1007 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1018 S1018 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K1023 N1023 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1117 N1117 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K1195 T1195 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1223 N1223 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1302 I1302 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S1302 R1302 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1304 C1304 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
K1405 N1405 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1433 E1433 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T1438 I1438 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T1525 M1525 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
R1539 I1539 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1561 F1561 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1561 P1561 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1583 F1583 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1588 F1588 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
S1678 L1678 Biomuta DOID:363 / uterine cancer [ icgc ]
S1679 P1679 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1752 I1752 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1752 Y1752 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1812 L1812 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]