iPTMnet Report for Q9Y478 (PRKAB1)
Protein Information
UniProt AC / UniProt ID | Q9Y478 / AAKB1_HUMAN |
Protein Name | 5'-AMP-activated protein kinase subunit beta-1 |
Gene Name | Name: PRKAB1 Synonyms:AMPK; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9Y478 |
PRO Name | 5'-AMP-activated protein kinase subunit beta-1 (human) |
Definition | A 5'-AMP-activated protein kinase subunit beta-1 that is encoded in the genome of human. |
Short Label | hPRKAB1 |
Category | organism-gene |
Q9Y478 (PRKAB1) as Substrate
Site | PTM Type | PTM Enzyme |
Score
| Source | PMID | |
---|---|---|---|---|---|---|
G2 | Myristoylation | score2 | UniProt | 21680840 | ||
T4 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18088087 | ||
S5 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18088087 | ||
S6 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18088087 | ||
T19 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 18691976, 20068231, 19369195 | ||
S24 | Phosphorylation | Q13131 (PRKAA1) | score4 | HPRD phospho.ELM PhosphoSitePlus | 9305909, 19376078 | |
S25 | Phosphorylation | score1 | PhosphoSitePlus | |||
T28 | Phosphorylation | score1 | PhosphoSitePlus | |||
K35 | Ubiquitination | score1 | PhosphoSitePlus | |||
S40 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 18691976, 23186163, 20068231, ...19369195 | ||
S49 | Phosphorylation | score1 | PhosphoSitePlus | |||
K53 | Ubiquitination | score1 | PhosphoSitePlus | |||
K57 | Ubiquitination | score1 | PhosphoSitePlus | |||
K72 | Ubiquitination | score1 | PhosphoSitePlus | |||
T80 | Phosphorylation | Q13131 (PRKAA1) | score2 | PhosphoSitePlus | 19376078 | |
K89 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y92 | Phosphorylation | score1 | PhosphoSitePlus | |||
S94 | Phosphorylation | score1 | PhosphoSitePlus | |||
S96 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 19690332, 24275569 | ||
S101 | Phosphorylation | score1 | PhosphoSitePlus | |||
K102 | Ubiquitination | score1 | PhosphoSitePlus | |||
S108 | Phosphorylation | Q13131 (PRKAA1) | score4 | HPRD phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 19651622, 18691976, 21406692, ...19376078, 18088087, 19369195, 20230923, 28924239, 9305909, 18669648, 24275569, 22363791, 20166139, 23186163, 17728241, 19690332, 20068231 | |
S138 | Phosphorylation | score1 | PhosphoSitePlus | |||
S144 | Phosphorylation | score1 | PhosphoSitePlus | |||
T148 | Phosphorylation | Q13131 (PRKAA1) | score4 | PhosphoSitePlus RLIMS-P UniProt | 19369195, 26831516, 25792737 | |
K157 | Ubiquitination | score1 | PhosphoSitePlus | |||
T158 | Phosphorylation | Q13131 (PRKAA1) | score2 | PhosphoSitePlus | 19376078 | |
S170 | Phosphorylation | score1 | PhosphoSitePlus | |||
S174 | Phosphorylation | Q13131 (PRKAA1) | score2 | PhosphoSitePlus | 19376078 | |
S177 | Phosphorylation | Q13131 (PRKAA1) | score2 | PhosphoSitePlus | 19376078 | |
S180 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus | 18691976, 18669648 | ||
S181 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18691976, 18669648 | ||
S182 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 9305909 | ||
Y187 | Phosphorylation | score1 | PhosphoSitePlus | |||
K195 | Ubiquitination | score1 | PhosphoSitePlus | |||
S252 | Phosphorylation | score0 | HPRD | 18691976 | ||
T254 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y261 | Phosphorylation | score1 | PhosphoSitePlus | |||
K268 | Ubiquitination | score1 | PhosphoSitePlus |
Q9Y478 (PRKAB1) as PTM Enzyme
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S24 | T24 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K53 | N53 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
K72 | E72 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
S182 | Y182 | Biomuta | [ cosmic ] | |
K195 | R195 | Biomuta | DOID:1612 / breast cancer [ cosmic ] |
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