iPTMnet Report for Q9Y3Y2 (CHTOP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y3Y2 / CHTOP_HUMAN
Protein Name Chromatin target of PRMT1 protein
Gene Name Name: CHTOP
Synonyms:C1orf77,FOP;ORFNames:HT031,PP7704;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y3Y2
DAG View
PRO Name chromatin target of PRMT1 protein (human)
Definition A chromatin target of PRMT1 protein that is encoded in the genome of human.
Short Label hCHTOP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y3Y2 (CHTOP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K8 Ubiquitination PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
K30 Acetylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
T33 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S40 Phosphorylation PhosphoSitePlus   UniProt 23186163
S49 Phosphorylation PhosphoSitePlus   UniProt 23186163
S64 Phosphorylation PhosphoSitePlus   UniProt 23186163
K70 Acetylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
R87 Methylation PhosphoSitePlus
R90 Methylation PhosphoSitePlus
R97 Methylation PhosphoSitePlus
R103 Methylation PhosphoSitePlus
R110 Methylation PhosphoSitePlus
R114 Methylation PhosphoSitePlus
R118 Methylation PhosphoSitePlus
R121 Methylation PhosphoSitePlus
R128 Methylation PhosphoSitePlus
R134 Methylation PhosphoSitePlus
R140 Methylation PhosphoSitePlus
R143 Methylation PhosphoSitePlus
R148 Methylation PhosphoSitePlus
R152 Methylation PhosphoSitePlus
R153 Methylation PhosphoSitePlus
R157 Methylation PhosphoSitePlus
R159 Methylation PhosphoSitePlus
R164 Methylation PhosphoSitePlus
R169 Methylation PhosphoSitePlus
R174 Methylation PhosphoSitePlus
R180 Methylation PhosphoSitePlus
R182 Methylation PhosphoSitePlus
R187 Methylation PhosphoSitePlus
R189 Methylation PhosphoSitePlus
R203 Methylation PhosphoSitePlus
R208 Methylation PhosphoSitePlus
T212 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
K213 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
T227 Phosphorylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
T242 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T33 Phosphorylation HPRD 19007248, 20068231, 19691289
S40 Phosphorylation HPRD 19007248, 19691289
T227 Phosphorylation HPRD 20068231
T242 Phosphorylation HPRD 17081983, 20068231
T246 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
R128 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K28 N28 Biomuta DOID:363 / uterine cancer [ tcga ]
T33 M33 Biomuta DOID:1324 / lung cancer [ icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ]
S40 L40 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K81 M81 Biomuta DOID:0070003 / blastoma [ cosmic ]
K81 N81 Biomuta DOID:1115 / sarcoma [ tcga ]
R90 * Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
R97 S97 Biomuta DOID:3571 / liver cancer [ icgc ]
R103 * Biomuta DOID:363 / uterine cancer [ tcga ]
R103 Q103 Biomuta DOID:1324 / lung cancer [ tcga ]
R103 L103 Biomuta DOID:1324 / lung cancer [ tcga ]
R118 C118 Biomuta DOID:363 / uterine cancer [ tcga ]
R121 C121 Biomuta DOID:363 / uterine cancer [ tcga ]
R121 H121 Biomuta DOID:1324 / lung cancer [ tcga ]
R134 * Biomuta DOID:363 / uterine cancer [ tcga ]
R134 Q134 Biomuta DOID:5041 / esophageal cancer [ icgc ]
R140 Q140 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
R143 Q143 Biomuta DOID:10534 / stomach cancer [ tcga ]
R143 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R148 * Biomuta DOID:363 / uterine cancer [ icgc, tcga ] DOID:1324 / lung cancer [ tcga ]
R157 L157 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R157 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R159 H159 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
R169 C169 Biomuta DOID:363 / uterine cancer [ tcga ]
R182 W182 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
R182 L182 Biomuta DOID:3571 / liver cancer [ icgc ]
R187 W187 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R187 Q187 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R208 C208 Biomuta DOID:363 / uterine cancer [ tcga ]
K226 Q226 Biomuta DOID:263 / kidney cancer [ cosmic ]