iPTMnet Report for Q9Y3S1 (WNK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y3S1 / WNK2_HUMAN
Protein Name Serine/threonine-protein kinase WNK2
Gene Name Name: WNK2
Synonyms:KIAA1760;ORFNames:P/OKcl.13;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y3S1
DAG View
PRO Name serine/threonine-protein kinase WNK2 (human)
Definition A serine/threonine-protein kinase WNK2 that is encoded in the genome of human.
Short Label hWNK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y3S1 (WNK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T13 Phosphorylation PhosphoSitePlus
R19 Methylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus   UniProt 21733846
S49 Phosphorylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus
T347 Phosphorylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus
T473 Phosphorylation PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus   UniProt 21733846
S1150 Phosphorylation PhosphoSitePlus   UniProt 21733846
S1152 Phosphorylation PhosphoSitePlus
T1175 Phosphorylation PhosphoSitePlus
S1262 Phosphorylation PhosphoSitePlus   UniProt 21733846
S1271 Phosphorylation PhosphoSitePlus
S1588 Phosphorylation PhosphoSitePlus   UniProt 21733846
T1604 O-Glycosylation GlyGen 30397120, 32574038, 21740066, ...35254053, 20305658, 28657654
S1605 O-Glycosylation GlyGen 30397120, 32574038, 32938750, ...21740066, 30620550, 20305658, 35254053, 28657654
T1611 O-Glycosylation GlyGen 32574038
T1611 Phosphorylation PhosphoSitePlus
R1631 Methylation PhosphoSitePlus
S1685 Phosphorylation PhosphoSitePlus   UniProt 21733846
S1689 Phosphorylation PhosphoSitePlus
Y1693 Phosphorylation PhosphoSitePlus
S1736 Phosphorylation PhosphoSitePlus   UniProt 21733846
S1777 Phosphorylation PhosphoSitePlus
S1798 Phosphorylation PhosphoSitePlus
S1801 Phosphorylation PhosphoSitePlus
S1805 Phosphorylation PhosphoSitePlus
S1817 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 21733846
S1818 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 21733846
S1843 Phosphorylation PhosphoSitePlus
S1844 Phosphorylation PhosphoSitePlus
S1846 Phosphorylation PhosphoSitePlus
S1862 Phosphorylation PhosphoSitePlus   UniProt 21733846
S1889 Phosphorylation PhosphoSitePlus
T1894 Phosphorylation PhosphoSitePlus
S1936 Phosphorylation PhosphoSitePlus
S2056 O-Glycosylation GlyGen 30397120, 32574038, 21740066, ...35254053, 20305658, 28657654
S2056 Phosphorylation PhosphoSitePlus
S2067 Phosphorylation PhosphoSitePlus   UniProt 21733846
T2078 Phosphorylation PhosphoSitePlus
S2091 Phosphorylation PhosphoSitePlus
S2101 Phosphorylation PhosphoSitePlus
S2110 Phosphorylation PhosphoSitePlus
S2128 Phosphorylation PhosphoSitePlus
S2129 Phosphorylation PhosphoSitePlus
K2155 Ubiquitination PhosphoSitePlus
T2157 Phosphorylation PhosphoSitePlus
T2159 Phosphorylation PhosphoSitePlus
T2173 Phosphorylation PhosphoSitePlus


Q9Y3S1 (WNK2) as PTM Enzyme



Substrate Site Score Source PMID
Q9H4A3 (WNK1) S382 neXtProt   PhosphoSitePlus   Signor 22032326
Q9UEW8 (STK39) T354 PhosphoSitePlus 21733846
Q9UEW8 (STK39) S371 PhosphoSitePlus 21733846


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S560 I560 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1150 N1150 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1605 F1605 Biomuta [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ]
R1631 H1631 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1631 L1631 Biomuta DOID:1324 / lung cancer [ cosmic ]
R1631 C1631 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1685 L1685 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1689 N1689 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1889 L1889 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1936 N1936 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T2078 M2078 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S2091 P2091 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2101 R2101 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S2101 N2101 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T2173 M2173 Biomuta DOID:10534 / stomach cancer [ cosmic ]