iPTMnet Report for Q9Y3Q7 (ADAM18)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y3Q7 / ADA18_HUMAN
Protein Name Disintegrin and metalloproteinase domain-containing protein 18 precursor
Gene Name Name: ADAM18
Synonyms:TMDC3;ORFNames:UNQ858/PRO1867;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y3Q7
DAG View
PRO Name disintegrin and metalloproteinase domain-containing protein 18 (human)
Definition A disintegrin and metalloproteinase domain-containing protein 18 that is encoded in the genome of human.
Short Label hADAM18
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y3Q7 (ADAM18) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y56 Phosphorylation PhosphoSitePlus
T57 Phosphorylation PhosphoSitePlus
T341 Phosphorylation PhosphoSitePlus
Y420 Phosphorylation PhosphoSitePlus
K440 Methylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y56 F56 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T57 I57 Biomuta DOID:4159 / skin cancer [ cosmic ]
T341 I341 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
Y420 N420 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y420 S420 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S589 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S589 L589 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]