iPTMnet Report for Q9Y3Q4 (HCN4)
Protein Information
| UniProt AC / UniProt ID | Q9Y3Q4 / HCN4_HUMAN |
| Protein Name | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 |
| Gene Name | Name: HCN4 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9Y3Q4 |
| PRO Name | potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human) |
| Definition | A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of human. |
| Short Label | hHCN4 |
| Category | organism-gene |
DAG ViewQ9Y3Q4 (HCN4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S14 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 2071354 | ||
| S14 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| S67 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S69 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S99 | Phosphorylation | score2 | neXtProt | 2071354 | ||
| S99 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| S110 | Phosphorylation | score2 | neXtProt | 2071354 | ||
| S110 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| S117 | Phosphorylation | score2 | neXtProt | 2071354 | ||
| S117 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| S230 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S236 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y531 | Phosphorylation | score3 | PhosphoSitePlus Signor | 17977941 | ||
| Y531 | Phosphorylation | P12931 (SRC) | score3 | PhosphoSitePlus Signor | 17977941 | |
| Y554 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T650 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S719 | Phosphorylation | score2 | neXtProt | 2071354 | ||
| S719 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| S831 | Phosphorylation | score2 | neXtProt | 2071354 | ||
| S831 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| S917 | Phosphorylation | score2 | neXtProt | 2071354 | ||
| S917 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| S921 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1005 | Phosphorylation | score2 | neXtProt | 2071354 | ||
| S1005 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| S1011 | Phosphorylation | score2 | neXtProt | 2071354 | ||
| S1011 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| S1015 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1020 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1026 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1051 | Phosphorylation | score2 | neXtProt | 2071354 | ||
| S1051 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| T1071 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 2071354 | ||
| T1071 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| T1075 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1112 | Phosphorylation | score2 | neXtProt | 2071354 | ||
| S1112 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| S1131 | Phosphorylation | score2 | neXtProt | 2071354 | ||
| S1131 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| T1156 | Phosphorylation | score2 | neXtProt | 2071354 | ||
| T1156 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| S1157 | Phosphorylation | score2 | neXtProt | 2071354 | ||
| S1157 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| S1158 | Phosphorylation | score2 | neXtProt | 2071354 | ||
| S1158 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 | |
| S1160 | Phosphorylation | score2 | neXtProt | 2071354 | ||
| S1160 | Phosphorylation | P17612 (PRKACA) | score2 | neXtProt | 2071354 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S831 | Y831 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S1160 | F1160 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] |
