Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y3I0 / RTCB_HUMAN
Protein Name RNA-splicing ligase RtcB homolog
Gene Name Name: RTCB
Synonyms:C22orf28;ORFNames:HSPC117;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y3I0
DAG View
PRO Name RNA-splicing ligase RtcB homolog (human)
Definition An RNA-splicing ligase RtcB that is encoded in the genome of human.
Short Label hrtcB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y3I0 (RTCB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K14 Acetylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
K17 Acetylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
R51 Methylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
R81 Methylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K245 Acetylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K285 Acetylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
R291 Methylation PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y306 Phosphorylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
Y349 Phosphorylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
S439 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
K465 Ubiquitination PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K496 Acetylation PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
K504 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K17 T17 Biomuta DOID:363 / uterine cancer [ tcga ]
R81 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R81 Q81 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K190 N190 Biomuta DOID:5041 / esophageal cancer [ tcga ]
R291 W291 Biomuta DOID:363 / uterine cancer [ tcga ]
T369 K369 Biomuta DOID:3571 / liver cancer [ icgc ]