iPTMnet Report for Q9Y3D6 (FIS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y3D6 / FIS1_HUMAN
Protein Name Mitochondrial fission 1 protein
Gene Name Name: FIS1
Synonyms:TTC11;ORFNames:CGI-135;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y3D6
DAG View
PRO Name mitochondrial fission 1 protein (human)
Definition A mitochondrial fission 1 protein that is encoded in the genome of human.
Short Label hFIS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y3D6 (FIS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO   UniProt 19413330, 25944712
S10 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29480948, 24275569
K25 Ubiquitination PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
T34 Phosphorylation RLIMS-P 35290083
Y38 Phosphorylation PhosphoSitePlus
K46 Acetylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
Y82 Phosphorylation PhosphoSitePlus
Y87 Phosphorylation PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K149 Sumoylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036281 (hFIS1/Ac:1) acM1 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9Y3D6 (FIS1) T34 P46939 (UTRN) increased_association eFIP 35290083


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 A10 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S31 A31 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y82 C82 Biomuta DOID:1324 / lung cancer [ cosmic ]