iPTMnet Report for Q9Y3B8 (REXO2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y3B8 / ORN_HUMAN
Protein Name Oligoribonuclease, mitochondrial precursor
Gene Name Name: REXO2
Synonyms:SFN,SMFN;ORFNames:CGI-114;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y3B8
DAG View
PRO Name oligoribonuclease, mitochondrial (human)
Definition An oligoribonuclease, mitochondrial that is encoded in the genome of human.
Short Label hREXO2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y3B8 (REXO2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
R9 Methylation PhosphoSitePlus
R12 Methylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus   UniProt 24275569
K98 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
Y122 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455, 18083107
K148 Ubiquitination PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
K173 Acetylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
Y184 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
K189 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K205 Acetylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
R211 Methylation PhosphoSitePlus
K216 Acetylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y122 Phosphorylation HPRD 15592455, 18083107
Y184 Phosphorylation HPRD 15592455


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R12 W12 Biomuta DOID:363 / uterine cancer [ icgc ]
K108 Q108 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y122 F122 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R211 * Biomuta DOID:3571 / liver cancer [ cosmic ]
R211 Q211 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K216 Q216 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]