iPTMnet Report for Q9Y320 (TMX2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y320 / TMX2_HUMAN
Protein Name Thioredoxin-related transmembrane protein 2 precursor
Gene Name Name: TMX2
Synonyms:TXNDC14;ORFNames:CGI-31,My009,PIG26,PSEC0045,UNQ237/PRO270;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y320
DAG View
PRO Name thioredoxin-related transmembrane protein 2 (human)
Definition A thioredoxin-related transmembrane protein 2 that is encoded in the genome of human.
Short Label hTMX2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y320 (TMX2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S73 Phosphorylation PhosphoSitePlus
K79 Acetylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
T85 Phosphorylation PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
Y206 Phosphorylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
T210 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus   UniProt 23186163
K215 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus   UniProt 19690332
K269 Ubiquitination PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
T283 Phosphorylation PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
K293 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T210 Phosphorylation HPRD 19413330
S211 Phosphorylation HPRD 19413330
S282 Phosphorylation HPRD 18669648
T285 Phosphorylation HPRD 18669648
T286 Phosphorylation HPRD 18669648
S288 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S83 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T187 A187 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K227 M227 Biomuta DOID:1324 / lung cancer [ cosmic ]
S243 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S282 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S288 L288 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K293 R293 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]