iPTMnet Report for Q9Y2Z4 (YARS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2Z4 / SYYM_HUMAN
Protein Name Tyrosine--tRNA ligase, mitochondrial precursor
Gene Name Name: YARS2
ORFNames:CGI-04;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2Z4
DAG View
PRO Name tyrosine--tRNA ligase, mitochondrial (human)
Definition A tyrosine--tRNA ligase, mitochondrial that is encoded in the genome of human.
Short Label hYARS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2Z4 (YARS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K43 Ubiquitination PhosphoSitePlus
K49 Acetylation PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
Y255 Phosphorylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
T297 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
Y303 Phosphorylation PhosphoSitePlus
R308 Methylation PhosphoSitePlus
T354 O-Glycosylation GlyGen 30379171, 34725712, 34229054
K355 Acetylation PhosphoSitePlus   UniProt 19608861
K355 Ubiquitination PhosphoSitePlus
K367 Acetylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
Y426 Phosphorylation PhosphoSitePlus
S435 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S245 C245 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T297 A297 Biomuta DOID:363 / uterine cancer [ cosmic ]
S298 F298 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y303 C303 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R308 G308 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y426 D426 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]