Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2X9 / ZN281_HUMAN
Protein Name Zinc finger protein 281
Gene Name Name: ZNF281
Synonyms:GZP1,ZBP99;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2X9
DAG View
PRO Name zinc finger protein 281 (human)
Definition A zinc finger protein 281 that is encoded in the genome of human.
Short Label hZNF281
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2X9 (ZNF281) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K2 Sumoylation PhosphoSitePlus
S5 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
S16 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
S16 Phosphorylation PhosphoSitePlus
S20 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
K102 Ubiquitination PhosphoSitePlus
S107 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
S117 Phosphorylation PhosphoSitePlus
K128 Sumoylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
T209 Phosphorylation PhosphoSitePlus
K213 Sumoylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K225 Sumoylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
K232 Sumoylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
K259 Sumoylation PhosphoSitePlus
T284 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K315 Ubiquitination PhosphoSitePlus
K325 Sumoylation PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
K329 Sumoylation PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K346 Sumoylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
Y353 Phosphorylation PhosphoSitePlus
K373 Sumoylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
S382 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
S395 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
K409 Sumoylation PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
K416 Sumoylation PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
T443 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
S445 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
S445 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
S447 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
T453 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
K464 Sumoylation PhosphoSitePlus
K477 Sumoylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
Y479 Phosphorylation PhosphoSitePlus
S484 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K493 Sumoylation PhosphoSitePlus
K498 Sumoylation PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
Y531 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
K539 Sumoylation PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
K599 Ubiquitination PhosphoSitePlus
S600 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S615 Phosphorylation PhosphoSitePlus
K617 Ubiquitination PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
K622 Sumoylation PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
T637 Phosphorylation PhosphoSitePlus
S638 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P   Signor 29179460
S642 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T654 Phosphorylation PhosphoSitePlus
T656 Phosphorylation PhosphoSitePlus
K661 Ubiquitination PhosphoSitePlus
K670 Sumoylation PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
S679 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
S683 Phosphorylation PhosphoSitePlus
T685 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
S694 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
S696 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
S697 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
S697 Phosphorylation PhosphoSitePlus
T703 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
T713 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
S783 Phosphorylation PhosphoSitePlus
S785 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
K787 Sumoylation PhosphoSitePlus
K787 Ubiquitination PhosphoSitePlus
K792 Acetylation PhosphoSitePlus
K795 Sumoylation PhosphoSitePlus
K795 Ubiquitination PhosphoSitePlus
S800 Phosphorylation PhosphoSitePlus
S807 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
S812 Phosphorylation PhosphoSitePlus
K818 Ubiquitination PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus
K840 Sumoylation PhosphoSitePlus
K840 Ubiquitination PhosphoSitePlus
S853 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
T863 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
S864 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
S864 Phosphorylation PhosphoSitePlus
S866 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
T872 Phosphorylation PhosphoSitePlus
K887 Ubiquitination PhosphoSitePlus
T888 Phosphorylation PhosphoSitePlus   UniProt 24275569
S891 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 30059200, 29351928, ...26280087, 20068230
S893 O-Glycosylation GlyGen 23301498, 26280087, 20068230, ...30059200, 29351928
Site PTM Type PTM Enzyme Score Source PMID
S36 Phosphorylation HPRD 20068231
T116 Phosphorylation HPRD 20068231
S160 Phosphorylation HPRD 20068231
S255 Phosphorylation HPRD 19413330
T284 Phosphorylation HPRD 18669648
S395 Phosphorylation HPRD 17525332, 18077418
S484 Phosphorylation HPRD 19413330, 18669648
S600 Phosphorylation HPRD 18669648
S651 Phosphorylation HPRD 18691976
T654 Phosphorylation HPRD 18691976
S785 Phosphorylation HPRD 17525332, 18077418
S807 Phosphorylation HPRD 17525332, 18077418


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9Y2X9 (ZNF281) S638 Q9UKB1 (FBXW11) unknown eFIP 29179460


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S36 G36 Biomuta DOID:5041 / esophageal cancer [ icgc ]
K128 N128 Biomuta DOID:363 / uterine cancer [ tcga ]
T209 P209 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K259 R259 Biomuta DOID:363 / uterine cancer [ tcga ]
K315 * Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K325 N325 Biomuta DOID:363 / uterine cancer [ tcga ]
K346 T346 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y353 F353 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K373 E373 Biomuta DOID:1324 / lung cancer [ cosmic ]
S410 G410 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S410 N410 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:363 / uterine cancer [ tcga ]
S447 C447 Biomuta DOID:3571 / liver cancer [ icgc ]
K464 Q464 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K477 E477 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S484 * Biomuta DOID:3571 / liver cancer [ icgc ]
K493 T493 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:3070 / malignant glioma [ tcga ]
K539 N539 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K599 E599 Biomuta DOID:5041 / esophageal cancer [ icgc ]
K617 Q617 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S638 * Biomuta DOID:3571 / liver cancer [ icgc ]
S638 L638 Biomuta DOID:1324 / lung cancer [ tcga ]
K670 T670 Biomuta DOID:363 / uterine cancer [ tcga ]
K670 E670 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K795 R795 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K795 T795 Biomuta DOID:363 / uterine cancer [ tcga ]
K795 N795 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:1909 / melanoma [ cosmic ]
S807 C807 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K840 N840 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
S853 C853 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S864 P864 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S866 * Biomuta DOID:3571 / liver cancer [ icgc ]
T872 K872 Biomuta DOID:3571 / liver cancer [ icgc ]
S891 I891 Biomuta DOID:1793 / pancreatic cancer [ tcga ]