Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2W1 / TR150_HUMAN
Protein Name Thyroid hormone receptor-associated protein 3
Gene Name Name: THRAP3
Synonyms:BCLAF2;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2W1
DAG View
PRO Name thyroid hormone receptor-associated protein 3 (human)
Definition A thyroid hormone receptor-associated protein 3 that is encoded in the genome of human.
Short Label hTHRAP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2W1 (THRAP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
S2 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
S24 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
S30 Phosphorylation phospho.ELM 17081983
S34 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S36 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S38 Phosphorylation PhosphoSitePlus
S46 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S47 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S51 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 17081983, 20068231
S53 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 17081983, 20068231, ...18452278
Y54 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231
S55 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 17081983, 20068231, ...18452278
R62 Methylation PhosphoSitePlus
R66 Methylation PhosphoSitePlus   UniProt 24129315
Y68 Phosphorylation P12931 (SRC) PhosphoSitePlus 18698806
R71 Methylation PhosphoSitePlus
R74 Methylation PhosphoSitePlus
R78 Methylation PhosphoSitePlus
R81 Methylation PhosphoSitePlus
R87 Methylation PhosphoSitePlus
R91 Methylation PhosphoSitePlus
R101 Methylation PhosphoSitePlus   UniProt 24129315
Y107 Phosphorylation P12931 (SRC) PhosphoSitePlus 18698806
R108 Methylation PhosphoSitePlus   UniProt 24129315
Y114 Phosphorylation PhosphoSitePlus
R115 Methylation PhosphoSitePlus
Y118 Phosphorylation P12931 (SRC) HPRD   PhosphoSitePlus 18698806, 17081983
S119 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231, 18212344
S134 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
S136 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
S139 Phosphorylation phospho.ELM 17081983
S143 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
K178 Acetylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
S187 Phosphorylation HPRD   PhosphoSitePlus 20068231
S190 Phosphorylation PhosphoSitePlus
K202 Methylation PhosphoSitePlus
K202 Sumoylation PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
S207 Phosphorylation HPRD   PhosphoSitePlus 19413330
T210 Phosphorylation HPRD   PhosphoSitePlus 19691289
S211 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 17525332, 15302935, ...20068231
T214 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
S220 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163
K221 Acetylation PhosphoSitePlus   UniProt 19608861
K221 Ubiquitination PhosphoSitePlus
T227 Phosphorylation PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus
T230 Phosphorylation HPRD   PhosphoSitePlus 20068231
S232 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18669648, 23186163, ...20068231
S234 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
S237 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935, 19691289, ...19651622, 18669648
S240 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18767875, ...19007248, 19691289, 17322306, 18669648, 20068231
S243 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15659558, 16964243, 15302935, ...18691976, 21406692, 23186163, 18212344, 19691289, 18452278, 19367720, 19413330, 18220336, 18767875, 20058876, 19007248, 19651622, 16083285, 17081983, 19664994, 19664995, 17322306, 18669648, 20166139, 19415658, 20068231, 17924679
S248 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26841317, 23186163, 17081983, ...18220336, 18767875, 19664994, 18452278, 19651622, 18669648, 24275569, 20068231, 17924679
K252 Methylation PhosphoSitePlus   UniProt 24129315
S253 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19651622, 21406692, 23186163, ...17081983, 18220336, 18767875, 20058876, 19007248, 18452278, 26841317, 19664994, 18669648, 17322306, 24275569, 17924679, 20068231, 20068230
S257 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 24275569, ...20068231
S264 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
S268 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 17081983, 20068231
S274 Phosphorylation PhosphoSitePlus
S295 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
T297 Phosphorylation HPRD 20068231
S310 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18452278
S312 Phosphorylation PhosphoSitePlus
S315 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17287340, ...17081983, 19651622, 17322306, 23186163, 20068231
S320 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 21406692, ...18491316, 17287340, 17081983, 20058876, 15302935, 19664995, 19007248, 19651622, 18669648, 24275569, 23186163, 18452278, 20068231, 19691289
S323 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 18452278, ...19651622, 18669648, 20068231
T324 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S326 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18452278
T327 Phosphorylation HPRD   PhosphoSitePlus 18452278
Y328 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18452278
S330 Phosphorylation PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
S339 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 20068231
Y344 Phosphorylation P12931 (SRC) PhosphoSitePlus 18698806
T345 Phosphorylation PhosphoSitePlus
Y348 Phosphorylation HPRD   PhosphoSitePlus 18452278
T365 Phosphorylation PhosphoSitePlus
T367 Phosphorylation PhosphoSitePlus
S377 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19691289, 19651622, ...24275569, 20068231
S379 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 15302935, ...23186163, 18212344, 17081983, 18767875, 19664994, 19664995, 18452278, 19651622, 17322306, 18669648, 19415658, 20068231, 19691289
T381 Phosphorylation HPRD   PhosphoSitePlus 20068231
K387 Acetylation PhosphoSitePlus
K387 Sumoylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S392 Phosphorylation HPRD   PhosphoSitePlus 20068231
T397 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S399 Phosphorylation PhosphoSitePlus
K401 Acetylation PhosphoSitePlus
S406 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 17081983, ...21406692, 19651622, 18669648, 20068231
S408 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 17525332, 19651622, 18669648, 20068231
Y412 Phosphorylation PhosphoSitePlus
K420 Acetylation PhosphoSitePlus
K427 Sumoylation PhosphoSitePlus
K442 Methylation PhosphoSitePlus
S444 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340, 19691289
K451 Sumoylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
K455 Acetylation PhosphoSitePlus   UniProt 19608861
K455 Ubiquitination PhosphoSitePlus
K461 Sumoylation PhosphoSitePlus
K467 Sumoylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus   UniProt 23186163
K470 Acetylation PhosphoSitePlus
K470 Sumoylation PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
Y476 Phosphorylation PhosphoSitePlus
K481 Acetylation PhosphoSitePlus
K483 Acetylation PhosphoSitePlus
K486 Sumoylation PhosphoSitePlus
T487 Phosphorylation PhosphoSitePlus
S494 Phosphorylation HPRD   PhosphoSitePlus 19651622
S499 Phosphorylation PhosphoSitePlus
K500 Methylation PhosphoSitePlus
S508 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
R513 Methylation PhosphoSitePlus
K519 Acetylation PhosphoSitePlus   UniProt 19608861
K519 Ubiquitination PhosphoSitePlus
Y526 Phosphorylation PhosphoSitePlus
K527 Acetylation PhosphoSitePlus
S534 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935, 20068231
S535 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 15302935, 17081983, ...20068231
K551 Ubiquitination PhosphoSitePlus
K558 Acetylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
S560 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569, ...20068231
S562 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19007248, 19691289
S575 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19007248, 19691289, 19651622, 18669648, 24275569, 18452278, 20068231
S584 Phosphorylation HPRD 20068231
S600 Phosphorylation HPRD   PhosphoSitePlus 20068231
S619 Phosphorylation PhosphoSitePlus   UniProt 23186163
S622 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 21406692, 17081983, ...20068231
S624 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
T633 Phosphorylation HPRD 17081983
K639 Acetylation PhosphoSitePlus
Y657 Phosphorylation PhosphoSitePlus
T662 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
S672 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17287340, 17081983, 18767875, ...19651622, 20068231
S682 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15659558, 16964243, 19664994, ...21406692, 23186163, 18212344, 20230923, 19691289, 18452278, 24275569, 19413330, 18220336, 18767875, 20058876, 19007248, 15144186, 19651622, 18491316, 17287340, 17081983, 15302935, 19664995, 17322306, 18669648, 20166139, 19415658, 20068231, 17924679
S684 Phosphorylation HPRD   PhosphoSitePlus   UniProt 17081983, 20230923, 19007248, ...19691289, 19651622, 24275569, 20166139, 18452278, 19415658, 20068231
T685 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20230923, 18220336, ...19007248, 18452278, 20166139, 19415658, 20068231
S698 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 21406692, 17287340, ...17081983, 18767875, 19651622, 22067460, 23186163, 20068231, 17924679
Y704 Phosphorylation PhosphoSitePlus
K705 Sumoylation PhosphoSitePlus
K709 Acetylation PhosphoSitePlus
Y710 Phosphorylation PhosphoSitePlus
K711 Methylation PhosphoSitePlus
K711 Sumoylation PhosphoSitePlus
S737 Phosphorylation PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
S743 Phosphorylation PhosphoSitePlus
S746 Phosphorylation PhosphoSitePlus
S747 Phosphorylation PhosphoSitePlus
S749 Phosphorylation PhosphoSitePlus
S753 Phosphorylation PhosphoSitePlus
K756 Sumoylation PhosphoSitePlus
K759 Sumoylation PhosphoSitePlus
S779 Phosphorylation HPRD 19651622
S784 Phosphorylation HPRD 19651622
S786 Phosphorylation PhosphoSitePlus
Y795 Phosphorylation PhosphoSitePlus
T796 Phosphorylation PhosphoSitePlus
T799 Phosphorylation PhosphoSitePlus
R802 Methylation PhosphoSitePlus
S805 Phosphorylation PhosphoSitePlus
T806 Phosphorylation PhosphoSitePlus
T807 Phosphorylation PhosphoSitePlus
K811 Acetylation PhosphoSitePlus   UniProt 19608861
K811 Ubiquitination PhosphoSitePlus
S823 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
R825 Methylation PhosphoSitePlus
R829 Methylation PhosphoSitePlus
R831 Methylation PhosphoSitePlus
T833 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
R837 Methylation PhosphoSitePlus
R839 Methylation PhosphoSitePlus
R841 Methylation PhosphoSitePlus
R845 Methylation PhosphoSitePlus
Y873 Phosphorylation PhosphoSitePlus
T874 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18212344, 18847512, ...19664994, 19664995, 16565220, 18669648, 18452278, 19690332, 20068231
K876 Ubiquitination PhosphoSitePlus
S877 Phosphorylation PhosphoSitePlus
K879 Acetylation PhosphoSitePlus
Y880 Phosphorylation PhosphoSitePlus
Y881 Phosphorylation PhosphoSitePlus
R886 Methylation PhosphoSitePlus
S891 Phosphorylation PhosphoSitePlus
R897 Methylation PhosphoSitePlus
R899 Methylation PhosphoSitePlus
R906 Methylation PhosphoSitePlus
R908 Methylation PhosphoSitePlus
R910 Methylation PhosphoSitePlus
S916 O-Glycosylation GlyGen 32119511, 29351928
S916 Phosphorylation PhosphoSitePlus
S917 Phosphorylation PhosphoSitePlus
T918 Phosphorylation PhosphoSitePlus
S919 Phosphorylation PhosphoSitePlus
K926 Acetylation PhosphoSitePlus
S928 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 18318008, 19651622, 18669648, 20166139, 18452278, 19690332, 20068231
S939 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17287340, ...17081983, 18767875, 15302935, 19691289, 18452278, 19651622, 19664994, 18669648, 20166139, 23186163, 19690332, 20068231
T941 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 17287340, 17081983, ...18452278, 19651622, 18669648, 20166139, 20068231
T953 Phosphorylation PhosphoSitePlus
T954 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S24 P24 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S28 L28 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ tcga ]
S30 Y30 Biomuta DOID:3070 / malignant glioma [ tcga ]
R62 I62 Biomuta DOID:363 / uterine cancer [ tcga ]
R62 K62 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
R66 I66 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:1115 / sarcoma [ tcga ]
R71 Q71 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
R74 * Biomuta DOID:2531 / hematologic cancer [ icgc ]
R74 Q74 Biomuta DOID:363 / uterine cancer [ cosmic ]
R101 * Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:10534 / stomach cancer [ icgc, tcga ]
R101 P101 Biomuta DOID:1612 / breast cancer [ tcga ]
R101 Q101 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
Y107 S107 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
R108 C108 Biomuta DOID:1909 / melanoma [ cosmic ]
Y114 H114 Biomuta DOID:0070003 / blastoma [ cosmic ]
R115 W115 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S143 C143 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S150 Y150 Biomuta DOID:363 / uterine cancer [ tcga ]
S184 F184 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S207 Y207 Biomuta DOID:3070 / malignant glioma [ tcga ]
S211 Y211 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S217 Y217 Biomuta DOID:363 / uterine cancer [ tcga ]
S240 Y240 Biomuta DOID:363 / uterine cancer [ tcga ]
S253 N253 Biomuta DOID:363 / uterine cancer [ tcga ]
T345 K345 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S377 R377 Biomuta DOID:2394 / ovarian cancer [ tcga ]
T381 K381 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K442 N442 Biomuta DOID:1324 / lung cancer [ cosmic ]
K451 T451 Biomuta DOID:363 / uterine cancer [ tcga ]
S468 L468 Biomuta DOID:1612 / breast cancer [ tcga ]
S468 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S494 F494 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K527 E527 Biomuta DOID:363 / uterine cancer [ tcga ]
K551 R551 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S560 F560 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S575 C575 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S682 F682 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S698 R698 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S737 L737 Biomuta DOID:363 / uterine cancer [ tcga ]
S746 F746 Biomuta DOID:3070 / malignant glioma [ tcga ]
S779 Y779 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S786 L786 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T807 A807 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
R831 Q831 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R831 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
R837 * Biomuta DOID:2531 / hematologic cancer [ tcga ]
R841 T841 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R845 T845 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y873 C873 Biomuta DOID:10534 / stomach cancer [ tcga ]
Y880 C880 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R886 H886 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R886 C886 Biomuta DOID:10534 / stomach cancer [ icgc, tcga ]
R897 W897 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R899 W899 Biomuta DOID:10534 / stomach cancer [ tcga ]
R906 W906 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R908 Q908 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]