iPTMnet Report for Q9Y2U8 (LEMD3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2U8 / MAN1_HUMAN
Protein Name Inner nuclear membrane protein Man1
Gene Name Name: LEMD3
Synonyms:MAN1;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2U8
DAG View
PRO Name inner nuclear membrane protein Man1 (human)
Definition An inner nuclear membrane protein Man1 that is encoded in the genome of human.
Short Label hLEMD3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2U8 (LEMD3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S7 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
Y24 Phosphorylation PhosphoSitePlus
S27 O-Glycosylation GlyGen 30379171, 34019948, 35254053
S27 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T32 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S34 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
S56 O-Glycosylation GlyGen 30379171, 34019948, 35254053
S95 Phosphorylation PhosphoSitePlus
T103 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
S140 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18452278, 19651622, 18669648, ...19690332, 20068231
S141 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 20058876, 18452278, 19651622, ...18669648, 19690332, 20068231
S144 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 20058876, ...19664994, 18452278, 19651622, 18669648, 19415658, 19690332, 20068231
S149 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S164 Phosphorylation PhosphoSitePlus
Y167 Phosphorylation PhosphoSitePlus
S185 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S187 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18220336
T209 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
K213 Ubiquitination PhosphoSitePlus
Y258 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S259 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18452278, 19651622, ...18669648, 24275569
S261 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18452278, ...19651622, 18669648, 24275569, 19690332, 20068231
K277 Ubiquitination PhosphoSitePlus
S280 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T289 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
S331 Phosphorylation HPRD   PhosphoSitePlus 20068231, 17924679
C346 S-Nitrosylation dbSNO 26338901
S351 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S352 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
T365 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S377 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S381 Phosphorylation HPRD   PhosphoSitePlus 20068231
S382 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S399 Phosphorylation PhosphoSitePlus
S402 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18220336, 19166343, ...18669648, 20068231
K438 Ubiquitination PhosphoSitePlus
Y441 Phosphorylation PhosphoSitePlus
K443 Acetylation PhosphoSitePlus
K445 Acetylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
R537 Methylation PhosphoSitePlus
N576 N-Glycosylation GlyGen 24190977
T630 Phosphorylation PhosphoSitePlus
T632 Phosphorylation PhosphoSitePlus
Y651 Phosphorylation PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
K688 Ubiquitination PhosphoSitePlus
S728 Phosphorylation PhosphoSitePlus
C754 Methylation IEDB 31844290
K756 Ubiquitination PhosphoSitePlus
K763 Ubiquitination PhosphoSitePlus
S777 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S781 Phosphorylation PhosphoSitePlus
T783 Phosphorylation PhosphoSitePlus
K787 Ubiquitination PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
K837 Ubiquitination PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
Y843 Phosphorylation PhosphoSitePlus
K849 Ubiquitination PhosphoSitePlus
T883 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S888 Phosphorylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus
S896 Phosphorylation PhosphoSitePlus
S907 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18077418
S910 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S911 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9Y2U8 (LEMD3) S402 O75531 (BANF1) unknown eFIP 19166343


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 L7 Biomuta DOID:1612 / breast cancer [ icgc ]
K41 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S164 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K213 E213 Biomuta DOID:4159 / skin cancer [ cosmic ]
S280 F280 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S291 I291 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S351 C351 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S352 C352 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R537 Q537 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S728 C728 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C754 Y754 Biomuta DOID:1324 / lung cancer [ cosmic ]
S888 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S910 G910 Biomuta DOID:4606 / bile duct cancer [ cosmic ]