iPTMnet Report Q9Y2U5 MAP3K2

Protein Information

UniProt AC / UniProt ID	Q9Y2U5 / M3K2_HUMAN
Protein Name	Mitogen-activated protein kinase kinase kinase 2
Gene Name	Name: MAP3K2 Synonyms:MAPKKK2,MEKK2;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9Y2U5 DAG View
PRO Name	mitogen-activated protein kinase kinase kinase 2 (human)
Definition	A mitogen-activated protein kinase kinase kinase 2 that is encoded in the genome of human.
Short Label	hMAP3K2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9Y2U5 (MAP3K2) as Substrate

Q9Y2U5

Expanded View

Site	PTM Type	Score	Source	PMID
S26	Phosphorylation	score2	phospho.ELM PhosphoSitePlus UniProt	19369195, 18220336
S109	Phosphorylation	score1	PhosphoSitePlus
S153	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18691976, 23186163, 18212344, ...19369195, 18767875, 17322306, 18669648, 20166139, 20068231
T158	Phosphorylation	score2	HPRD PhosphoSitePlus	18691976, 20068231
S159	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18669648, 20068231
S163	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus	18691976, 18220336, 19651622, ...18669648, 20166139, 20068231
S164	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18088087, 18220336, 17192257, ...19651622, 18669648, 18707149, 20068231
Y169	Phosphorylation	score1	PhosphoSitePlus
S239	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18691976, 23186163, 18669648, ...20166139, 19690332
Y240	Phosphorylation	score1	PhosphoSitePlus
S248	Phosphorylation	score1	PhosphoSitePlus
Y250	Phosphorylation	score1	PhosphoSitePlus
K257	Ubiquitination	score1	PhosphoSitePlus
K260	Methylation	score1	PhosphoSitePlus
T263	Phosphorylation	score1	PhosphoSitePlus
T283	Phosphorylation	score3	PhosphoSitePlus RLIMS-P	23963453
T290	Phosphorylation	score1	PhosphoSitePlus
S297	Phosphorylation	score2	phospho.ELM PhosphoSitePlus UniProt	18220336
S300	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	18220336
S302	Phosphorylation	score1	PhosphoSitePlus
T310	Phosphorylation	score0	HPRD	18691976
S311	Phosphorylation	score2	HPRD PhosphoSitePlus UniProt	18691976, 23186163
S312	Phosphorylation	score2	HPRD PhosphoSitePlus	18691976
S314	Phosphorylation	score2	HPRD PhosphoSitePlus	18691976
S315	Phosphorylation	score2	HPRD PhosphoSitePlus	18691976
S331	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18691976, 23186163, 19369195, ...18669648, 24275569, 19690332
T337	Phosphorylation	score1	PhosphoSitePlus
S344	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus UniProt	18691976, 19369195, 19651622, ...18669648, 19690332
S347	Phosphorylation	score2	HPRD phospho.ELM PhosphoSitePlus	18691976, 18669648
S349	Phosphorylation	score2	HPRD PhosphoSitePlus	19651622, 18691976
K360	Ubiquitination	score1	PhosphoSitePlus
K385	Ubiquitination	score1	PhosphoSitePlus
K411	Ubiquitination	score1	PhosphoSitePlus
T432	Phosphorylation	score1	PhosphoSitePlus
K450	Ubiquitination	score1	PhosphoSitePlus
K485	Ubiquitination	score1	PhosphoSitePlus
S493	Phosphorylation	score1	PhosphoSitePlus
K498	Ubiquitination	score1	PhosphoSitePlus
S505	Phosphorylation	score1	PhosphoSitePlus
K506	Ubiquitination	score1	PhosphoSitePlus
S514	Phosphorylation	score1	PhosphoSitePlus
T516	Phosphorylation	score1	PhosphoSitePlus
S520	Phosphorylation	score1	PhosphoSitePlus
T522	Phosphorylation	score1	PhosphoSitePlus
T524	Phosphorylation	score1	PhosphoSitePlus
K581	Ubiquitination	score1	PhosphoSitePlus
K602	Ubiquitination	score1	PhosphoSitePlus

Q9Y2U5 (MAP3K2) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	O14733 (MAP2K7)	S271	score3	neXtProt	10347227, 10713157
	O14733 (MAP2K7)	T275	score3	neXtProt	10347227, 10713157

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
S26	F26	Biomuta	DOID:4159 / skin cancer [ cosmic ]
T283	A283	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
T283	P283	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
T310	A310	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]
S314	N314	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S315	R315	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S331	N331	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S344	N344	Biomuta	DOID:363 / uterine cancer [ icgc ]
S344	G344	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T432	P432	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S514	*	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
T516	A516	Biomuta	DOID:263 / kidney cancer [ cosmic ]
T524	K524	Biomuta	DOID:2394 / ovarian cancer [ cosmic, icgc ]
K581	R581	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K602	*	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ]
K602	R602	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q9Y2U5 (MAP3K2)

Protein Information

Interactive Sequence View

Q9Y2U5 (MAP3K2) as Substrate

Q9Y2U5 (MAP3K2) as PTM Enzyme

PTM sites affected in variants