iPTMnet Report for Q9Y2L9 (LRCH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2L9 / LRCH1_HUMAN
Protein Name Leucine-rich repeat and calponin homology domain-containing protein 1
Gene Name Name: LRCH1
Synonyms:CHDC1,KIAA1016;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2L9
DAG View
PRO Name leucine-rich repeat and calponin homology domain-containing protein 1 (human)
Definition A leucine-rich repeat and calponin homology domain-containing protein 1 that is encoded in the genome of human.
Short Label hLRCH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2L9 (LRCH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S156 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
C242 Methylation IEDB 31844290
C251 Methylation IEDB 31844290
S335 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S370 Phosphorylation IEDB   PhosphoSitePlus   UniProt 27920218, 32387766, 27869121, ...24275569
S385 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus   UniProt 23186163
S536 Phosphorylation PhosphoSitePlus   UniProt 23186163
T538 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
T568 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S623 Phosphorylation PhosphoSitePlus
S626 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T391 Phosphorylation HPRD 20068231
S532 Phosphorylation HPRD 20068231
S536 Phosphorylation HPRD 20068231
S562 Phosphorylation HPRD 20068231
T568 Phosphorylation HPRD 18669648, 19664994, 20068231
Site PTM Type PTM Enzyme Score Source PMID
K662 Ubiquitination PhosphoSitePlus
K673 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C242 S242 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S340 F340 Biomuta DOID:4159 / skin cancer [ cosmic ]
S346 G346 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S346 N346 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S365 L365 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S370 I370 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S532 F532 Biomuta DOID:4159 / skin cancer [ cosmic ]
S532 C532 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]