iPTMnet Report for Q9Y2L1 (DIS3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2L1 / RRP44_HUMAN
Protein Name Exosome complex exonuclease RRP44
Gene Name Name: DIS3
Synonyms:KIAA1008,RRP44;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2L1
DAG View
PRO Name exosome complex exonuclease RRP44 (human)
Definition An exosome complex exonuclease RRP44 that is encoded in the genome of human.
Short Label hDIS3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2L1 (DIS3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K5 Acetylation PhosphoSitePlus
R12 Methylation PhosphoSitePlus
K18 Acetylation PhosphoSitePlus   UniProt 19608861
K18 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
T113 Phosphorylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
T124 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
R178 Methylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
C194 Methylation IEDB 31844290
K199 Ubiquitination PhosphoSitePlus
R210 Methylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus   UniProt 23186163
K225 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
T250 Phosphorylation PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K331 Methylation PhosphoSitePlus
K331 Sumoylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K337 Acetylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
T608 Phosphorylation PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus
S634 Phosphorylation PhosphoSitePlus
K654 Ubiquitination PhosphoSitePlus
T659 Phosphorylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
K690 Ubiquitination PhosphoSitePlus
K704 Ubiquitination PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
K809 Ubiquitination PhosphoSitePlus
C814 Methylation IEDB 31844290
K815 Acetylation PhosphoSitePlus
K815 Ubiquitination PhosphoSitePlus
K822 Acetylation PhosphoSitePlus
K880 Ubiquitination PhosphoSitePlus
K895 Ubiquitination PhosphoSitePlus
K906 Ubiquitination PhosphoSitePlus
K910 Ubiquitination PhosphoSitePlus
K922 Acetylation PhosphoSitePlus
K922 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S164 L164 Biomuta DOID:3571 / liver cancer [ cosmic ]
R210 C210 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
K225 N225 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S599 A599 Biomuta [ cosmic ]
S599 L599 Biomuta DOID:4159 / skin cancer [ cosmic ]
S633 F633 Biomuta DOID:4159 / skin cancer [ cosmic ]
S634 F634 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T659 K659 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K677 Q677 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K815 T815 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]