Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2K7 / KDM2A_HUMAN
Protein Name Lysine-specific demethylase 2A
Gene Name Name: KDM2A
Synonyms:CXXC8,FBL11;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2K7
DAG View
PRO Name lysine-specific demethylase 2A (human)
Definition A lysine-specific demethylase 2A that is encoded in the genome of human.
Short Label hKDM2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2K7 (KDM2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S28 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19690332, 20068231
K43 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
S390 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S394 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
K409 Acetylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K505 Sumoylation PhosphoSitePlus
K518 Ubiquitination PhosphoSitePlus
T526 Phosphorylation PhosphoSitePlus
T534 Phosphorylation PhosphoSitePlus
T550 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18847512, ...18669648, 19690332, 20068231
S558 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18220336
S562 Phosphorylation PhosphoSitePlus
T632 Phosphorylation Q13315 (ATM) PhosphoSitePlus   RLIMS-P   UniProt 25823024, 17525332
S692 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19367720, 18669648, 23186163, ...19690332
K700 Ubiquitination PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
T713 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S718 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
T720 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S721 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S731 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S739 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S740 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
K791 Acetylation PhosphoSitePlus
S797 Phosphorylation PhosphoSitePlus
T802 Phosphorylation PhosphoSitePlus
T823 Phosphorylation PhosphoSitePlus
S825 Phosphorylation PhosphoSitePlus   UniProt 23186163
S826 Phosphorylation PhosphoSitePlus
S832 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T844 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S869 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S883 Phosphorylation PhosphoSitePlus   UniProt 20068231
K932 Ubiquitination PhosphoSitePlus
K951 Ubiquitination PhosphoSitePlus
S988 Phosphorylation PhosphoSitePlus
K1015 Ubiquitination PhosphoSitePlus
T1024 Phosphorylation PhosphoSitePlus
K1029 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S28 Phosphorylation HPRD 19651622, 17081983, 20068231, ...18452278
S390 Phosphorylation HPRD 18669648, 20068231
S394 Phosphorylation HPRD 18669648, 20068231
T534 Phosphorylation HPRD 17924679
T550 Phosphorylation HPRD 19651622, 18669648, 20068231
S558 Phosphorylation HPRD 19651622, 18669648, 20068231
T632 Phosphorylation HPRD 17525332
S692 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S707 Phosphorylation HPRD 20068231
T713 Phosphorylation HPRD 18669648, 20068231
S718 Phosphorylation HPRD 18669648, 20068231
T720 Phosphorylation HPRD 18669648, 20068231
S721 Phosphorylation HPRD 18669648
S731 Phosphorylation HPRD 18669648, 20068231
S739 Phosphorylation HPRD 17081983, 20068231
S832 Phosphorylation HPRD 18669648, 17081983, 20068231
T844 Phosphorylation HPRD 18669648, 17081983
S869 Phosphorylation HPRD 18669648, 19415658, 20068231, ...18452278
S883 Phosphorylation HPRD 19651622, 20068231
Y1094 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S390 F390 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K518 Q518 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T526 P526 Biomuta DOID:1612 / breast cancer [ icgc ]
T713 M713 Biomuta DOID:363 / uterine cancer [ tcga ]
S797 L797 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T802 M802 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T1024 I1024 Biomuta DOID:5041 / esophageal cancer [ icgc ]