iPTMnet Report for Q9Y2K6 (USP20)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2K6 / UBP20_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 20
Gene Name Name: USP20
Synonyms:KIAA1003,LSFR3A,VDU2;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2K6
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 20 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 20 that is encoded in the genome of human.
Short Label hUSP20
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2K6 (USP20) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K19 Ubiquitination PhosphoSitePlus
C86 Methylation IEDB 31844290
S103 Phosphorylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus   UniProt 23186163
S132 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 19651622, 18669648, 24275569, 20068231
S134 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 19651622, 18669648, 24275569, 20068231
K194 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
Y227 Phosphorylation PhosphoSitePlus
T258 Phosphorylation HPRD   UniProt 17081983
S263 Phosphorylation HPRD   PhosphoSitePlus 17081983
S265 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus   UniProt 23186163
S333 Phosphorylation PhosphoSitePlus   RLIMS-P 25666616
S333 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 25666616
T339 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
S372 Phosphorylation HPRD   PhosphoSitePlus 17081983
S373 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983
T377 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S390 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
S406 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S407 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648
S408 Phosphorylation PhosphoSitePlus   UniProt 23186163
S413 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163
S420 Phosphorylation PhosphoSitePlus
Y421 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
K553 Methylation PhosphoSitePlus
K835 Ubiquitination PhosphoSitePlus
K852 Ubiquitination PhosphoSitePlus
S854 Phosphorylation PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
K906 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S112 P112 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S112 F112 Biomuta DOID:4159 / skin cancer [ cosmic ]
T258 M258 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S277 N277 Biomuta DOID:1324 / lung cancer [ cosmic ]
S333 F333 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T339 I339 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S341 L341 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S390 Y390 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]