iPTMnet Report for Q9Y2I7 (PIKFYVE)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2I7 / FYV1_HUMAN
Protein Name 1-phosphatidylinositol 3-phosphate 5-kinase
Gene Name Name: PIKFYVE
Synonyms:KIAA0981,PIP5K3;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2I7
DAG View
PRO Name 1-phosphatidylinositol 3-phosphate 5-kinase (human)
Definition A 1-phosphatidylinositol 3-phosphate 5-kinase that is encoded in the genome of human.
Short Label hPIKFYVE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2I7 (PIKFYVE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19369195, 22814378
T3 Phosphorylation PhosphoSitePlus
T7 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus   UniProt 33098764
S23 Phosphorylation Q9Y2I7 (PIKFYVE) UniProt 33098764
T34 Phosphorylation PhosphoSitePlus
K43 Methylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
Y46 Phosphorylation phospho.ELM   PhosphoSitePlus 15144186
S48 Phosphorylation PhosphoSitePlus   UniProt 33098764, 23186163
S48 Phosphorylation Q9Y2I7 (PIKFYVE) UniProt 23186163
S76 Phosphorylation PhosphoSitePlus
T83 Phosphorylation PhosphoSitePlus
S88 Phosphorylation IEDB   PhosphoSitePlus   UniProt 32897882, 23186163
T90 O-Glycosylation GlyGen 29351928
T90 Phosphorylation PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
T133 Phosphorylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
Y154 Phosphorylation PhosphoSitePlus
T173 Phosphorylation PhosphoSitePlus
T253 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
S305 Phosphorylation PhosphoSitePlus
S307 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 15546921, 18669648, 23186163, ...24070423
S307 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 15546921
S307 Phosphorylation P54646 (PRKAA2) RLIMS-P+ 24070423
T309 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S318 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23757022, 19232516, ...20513353
S318 Phosphorylation O00141 (SGK1) PhosphoSitePlus 19232516
S318 Phosphorylation P31749 (AKT1) PhosphoSitePlus 23757022
Y324 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
S329 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T335 Phosphorylation PhosphoSitePlus
T339 Phosphorylation PhosphoSitePlus
T341 Phosphorylation PhosphoSitePlus
T342 Phosphorylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
T477 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
T583 Phosphorylation PhosphoSitePlus
K669 Acetylation PhosphoSitePlus
K675 Acetylation PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
K754 Ubiquitination PhosphoSitePlus
T822 Phosphorylation PhosphoSitePlus
S845 Phosphorylation PhosphoSitePlus
S888 Phosphorylation PhosphoSitePlus
K938 Ubiquitination PhosphoSitePlus
K944 Ubiquitination PhosphoSitePlus
K1046 Ubiquitination PhosphoSitePlus
S1111 Phosphorylation PhosphoSitePlus
S1124 Phosphorylation PhosphoSitePlus
Y1155 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K1165 Ubiquitination PhosphoSitePlus
S1167 Phosphorylation PhosphoSitePlus
S1177 Phosphorylation PhosphoSitePlus
K1206 Ubiquitination PhosphoSitePlus
S1301 Phosphorylation PhosphoSitePlus
T1312 Phosphorylation PhosphoSitePlus
Y1350 Phosphorylation PhosphoSitePlus
K1414 Ubiquitination PhosphoSitePlus
S1433 O-Glycosylation GlyGen 29351928
K1435 Ubiquitination PhosphoSitePlus
T1436 O-Glycosylation GlyGen 29351928
T1436 Phosphorylation PhosphoSitePlus
T1438 O-Glycosylation GlyGen 29351928
S1440 Phosphorylation PhosphoSitePlus
K1441 Ubiquitination PhosphoSitePlus
K1446 Ubiquitination PhosphoSitePlus
S1474 Phosphorylation PhosphoSitePlus
S1475 Phosphorylation PhosphoSitePlus
T1479 Phosphorylation PhosphoSitePlus
S1489 Phosphorylation PhosphoSitePlus
S1496 Phosphorylation PhosphoSitePlus
K1516 Ubiquitination PhosphoSitePlus
S1522 Phosphorylation PhosphoSitePlus   UniProt 33098764
S1522 Phosphorylation Q9Y2I7 (PIKFYVE) UniProt 33098764
S1526 Phosphorylation PhosphoSitePlus
S1544 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
S1549 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
S1669 Phosphorylation UniProt 33098764
S1669 Phosphorylation Q9Y2I7 (PIKFYVE) UniProt 33098764
K1689 Ubiquitination PhosphoSitePlus
S1712 Phosphorylation PhosphoSitePlus
S1714 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1741 Phosphorylation PhosphoSitePlus
S1754 Phosphorylation PhosphoSitePlus   UniProt 19369195
K1761 Ubiquitination PhosphoSitePlus
T1764 Phosphorylation PhosphoSitePlus
S1770 Phosphorylation PhosphoSitePlus
Y1772 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
Y1773 Phosphorylation PhosphoSitePlus
C1822 Methylation IEDB 31844290
K1832 Ubiquitination PhosphoSitePlus
K1861 Ubiquitination PhosphoSitePlus
K1953 Ubiquitination PhosphoSitePlus
K1967 Ubiquitination PhosphoSitePlus
S1969 Phosphorylation UniProt 33098764
S1969 Phosphorylation Q9Y2I7 (PIKFYVE) UniProt 33098764
T2026 Phosphorylation PhosphoSitePlus
Y2037 Phosphorylation PhosphoSitePlus
S2053 Phosphorylation UniProt 33098764
S2053 Phosphorylation Q9Y2I7 (PIKFYVE) UniProt 33098764
K2062 Ubiquitination PhosphoSitePlus
S2068 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation HPRD 18691976
T34 Phosphorylation HPRD 19413330
S71 Phosphorylation HPRD 18691976
S76 Phosphorylation HPRD 18691976
S299 Phosphorylation HPRD 18691976
S307 Phosphorylation HPRD 18691976, 20058876, 19664994, ...19664995, 18669648, 18767875
S318 Phosphorylation HPRD 18669648
S329 Phosphorylation HPRD 18669648
S352 Phosphorylation HPRD 18691976
S475 Phosphorylation HPRD 18691976, 18452278
T477 Phosphorylation HPRD 18691976
S491 Phosphorylation HPRD 18691976
T822 Phosphorylation HPRD 18491316
Y1155 Phosphorylation HPRD 17081983
S1544 Phosphorylation HPRD 18691976
S1549 Phosphorylation HPRD 18691976
S1712 Phosphorylation HPRD 18691976
S1714 Phosphorylation HPRD 18669648
S1754 Phosphorylation HPRD 18691976
Y1772 Phosphorylation HPRD 15592455
Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation HPRD 18691976
T34 Phosphorylation HPRD 19413330
S71 Phosphorylation HPRD 18691976
S76 Phosphorylation HPRD 18691976
S105 Phosphorylation PhosphoSitePlus
S202 Phosphorylation HPRD 18691976
S210 Phosphorylation HPRD 18691976, 20058876, 19664994, ...19664995, 18669648, 18767875
S221 Phosphorylation HPRD 18669648
S232 Phosphorylation HPRD 18669648
S255 Phosphorylation HPRD 18691976
S378 Phosphorylation HPRD 18691976, 18452278
T380 Phosphorylation HPRD 18691976
S394 Phosphorylation HPRD 18691976


Q9Y2I7 (PIKFYVE) as PTM Enzyme



Substrate Site Score Source PMID
P31749 (AKT1) S473 PhosphoSitePlus 12446602
Q9Y2I7 (PIKFYVE) S23 UniProt 33098764
Q9Y2I7 (PIKFYVE) S48 UniProt 23186163
Q9Y2I7 (PIKFYVE) S1522 UniProt 33098764
Q9Y2I7 (PIKFYVE) S1669 UniProt 33098764
Q9Y2I7 (PIKFYVE) S1969 UniProt 33098764
Q9Y2I7 (PIKFYVE) S2053 UniProt 33098764


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T3 A3 Biomuta DOID:363 / uterine cancer [ icgc ]
T7 K7 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S48 F48 Biomuta DOID:4159 / skin cancer [ cosmic ]
S104 C104 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K112 T112 Biomuta DOID:3571 / liver cancer [ cosmic ]
S202 F202 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S299 F299 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S305 L305 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T326 I326 Biomuta DOID:4159 / skin cancer [ cosmic ]
S327 F327 Biomuta DOID:1324 / lung cancer [ cosmic ]
T380 I380 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S394 C394 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]
S457 F457 Biomuta DOID:4159 / skin cancer [ cosmic ]
T477 I477 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S491 C491 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K578 E578 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K720 N720 Biomuta DOID:263 / kidney cancer [ cosmic ]
T822 N822 Biomuta DOID:1612 / breast cancer [ cosmic ]
K944 T944 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1046 N1046 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1111 C1111 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1165 T1165 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1433 F1433 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1438 A1438 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1446 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S1475 F1475 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1479 S1479 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
K1516 N1516 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1516 M1516 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1522 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1526 C1526 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1761 N1761 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
C1822 G1822 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1861 E1861 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S2053 L2053 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S2068 Y2068 Biomuta DOID:9256 / colorectal cancer [ cosmic ]