iPTMnet Report for Q9Y2I1 (NISCH)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2I1 / NISCH_HUMAN
Protein Name Nischarin
Gene Name Name: NISCH
Synonyms:IRAS,KIAA0975;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2I1
DAG View
PRO Name nischarin (human)
Definition A nischarin that is encoded in the genome of human.
Short Label hNISCH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2I1 (NISCH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S51 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
C403 Methylation IEDB 31844290
K454 Ubiquitination PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
C713 Methylation IEDB 31844290
S756 Phosphorylation PhosphoSitePlus
K843 Ubiquitination PhosphoSitePlus
K865 Ubiquitination PhosphoSitePlus
S883 Phosphorylation PhosphoSitePlus
K902 Ubiquitination PhosphoSitePlus
K942 Ubiquitination PhosphoSitePlus
S1004 Phosphorylation PhosphoSitePlus
K1009 Ubiquitination PhosphoSitePlus
K1015 Acetylation PhosphoSitePlus
K1015 Ubiquitination PhosphoSitePlus
S1022 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1038 Phosphorylation PhosphoSitePlus
S1200 Phosphorylation PhosphoSitePlus
C1257 Methylation IEDB 31844290
T1282 Phosphorylation PhosphoSitePlus
S1284 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
K1290 Ubiquitination PhosphoSitePlus
Y1293 Phosphorylation PhosphoSitePlus
S1294 Phosphorylation PhosphoSitePlus
K1299 Ubiquitination PhosphoSitePlus
K1303 Ubiquitination PhosphoSitePlus
Y1307 Phosphorylation PhosphoSitePlus
K1316 Ubiquitination PhosphoSitePlus
K1335 Ubiquitination PhosphoSitePlus
T1372 Phosphorylation PhosphoSitePlus
T1376 Phosphorylation PhosphoSitePlus
K1481 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S477 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P53667 (LIMK1) T508 Q9Y2I1 (NISCH) unknown eFIP 18332102


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S546 F546 Biomuta DOID:4159 / skin cancer [ cosmic ]
S756 F756 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1004 L1004 Biomuta DOID:363 / uterine cancer [ icgc ]
K1015 N1015 Biomuta DOID:363 / uterine cancer [ icgc ]
S1200 * Biomuta DOID:4159 / skin cancer [ cosmic ]
T1282 M1282 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S1284 L1284 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1290 N1290 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1294 F1294 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1303 N1303 Biomuta DOID:1319 / brain cancer [ icgc ]