iPTMnet Report for Q9Y2H5 (PLEKHA6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2H5 / PKHA6_HUMAN
Protein Name Pleckstrin homology domain-containing family A member 6
Gene Name Name: PLEKHA6
Synonyms:KIAA0969,PEPP3;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2H5
DAG View
PRO Name pleckstrin homology domain-containing family A member 6 (human)
Definition A pleckstrin homology domain-containing family A member 6 that is encoded in the genome of human.
Short Label hPLEKHA6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2H5 (PLEKHA6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation PhosphoSitePlus
K41 Methylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
R326 Methylation PhosphoSitePlus
R335 Methylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
Y341 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus
Y350 Phosphorylation PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
Y362 Phosphorylation PhosphoSitePlus
Y364 Phosphorylation PhosphoSitePlus
Y365 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
Y380 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
Y404 Phosphorylation PhosphoSitePlus
S426 Phosphorylation PhosphoSitePlus
Y433 Phosphorylation PhosphoSitePlus
Y434 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
S442 Phosphorylation HPRD   PhosphoSitePlus 19562805
S443 Phosphorylation HPRD   PhosphoSitePlus 19562805
R445 Methylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus   UniProt 24275569
S461 Phosphorylation PhosphoSitePlus   UniProt 24275569
S464 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
R469 Methylation PhosphoSitePlus
Y471 Phosphorylation PhosphoSitePlus
S472 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S476 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S478 Phosphorylation PhosphoSitePlus
R480 Methylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
Y492 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17016520, 17389395, 18083107, ...15951569
Y498 Phosphorylation PhosphoSitePlus
S503 Phosphorylation HPRD   phospho.ELM 18669648
S505 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S506 Phosphorylation PhosphoSitePlus
K532 Ubiquitination PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus   UniProt 24275569
R677 Methylation PhosphoSitePlus
Y686 Phosphorylation PhosphoSitePlus
T744 Phosphorylation PhosphoSitePlus
S749 Phosphorylation PhosphoSitePlus
T775 Phosphorylation HPRD   PhosphoSitePlus 20166139
S777 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18452278, 18669648, ...24275569, 20166139
T779 O-Glycosylation GlyGen 31373491
T779 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S794 Phosphorylation PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus
S842 Phosphorylation PhosphoSitePlus
S848 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16964243
S854 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16964243
S867 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S874 Phosphorylation PhosphoSitePlus
Y890 Phosphorylation PhosphoSitePlus
T920 Phosphorylation PhosphoSitePlus   UniProt 23186163
K923 Ubiquitination PhosphoSitePlus
T937 Phosphorylation PhosphoSitePlus
S940 Phosphorylation PhosphoSitePlus   UniProt 23186163
K945 Ubiquitination PhosphoSitePlus
S961 Phosphorylation PhosphoSitePlus
S974 Phosphorylation PhosphoSitePlus
S983 Phosphorylation PhosphoSitePlus
S1010 Phosphorylation PhosphoSitePlus
T1015 Phosphorylation PhosphoSitePlus
S1017 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1020 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T5 I5 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T5 A5 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y274 H274 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R326 W326 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R335 Q335 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S384 R384 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S442 I442 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R445 C445 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R445 H445 Biomuta DOID:363 / uterine cancer [ icgc ]
S448 F448 Biomuta DOID:4159 / skin cancer [ cosmic ]
S476 L476 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S506 F506 Biomuta DOID:4159 / skin cancer [ cosmic ]
S591 L591 Biomuta DOID:4159 / skin cancer [ cosmic ]
R677 I677 Biomuta DOID:363 / uterine cancer [ icgc ]
R677 K677 Biomuta DOID:4362 / cervical cancer [ cosmic ]
R677 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S777 L777 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
S848 I848 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S848 N848 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S867 I867 Biomuta DOID:1324 / lung cancer [ cosmic ]
S874 P874 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1010 F1010 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]