iPTMnet Report for Q9Y2F5 (ICE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2F5 / ICE1_HUMAN
Protein Name Little elongation complex subunit 1
Gene Name Name: ICE1
Synonyms:KIAA0947;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2F5
DAG View
PRO Name little elongation complex subunit 1 (human)
Definition A little elongation complex subunit 1 that is encoded in the genome of human.
Short Label hICE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2F5 (ICE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K43 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
Y116 Phosphorylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K163 Acetylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
T252 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19664995
S255 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S393 Phosphorylation PhosphoSitePlus
T438 O-Glycosylation GlyGen 23301498, 30379171, 35289036, ...35254053
T438 Phosphorylation PhosphoSitePlus
T444 Phosphorylation HPRD 20068231
S452 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
T484 Phosphorylation PhosphoSitePlus
T505 Phosphorylation PhosphoSitePlus
S514 Phosphorylation HPRD   PhosphoSitePlus 17924679
S516 Phosphorylation HPRD   PhosphoSitePlus 18691976, 19007248
K521 Ubiquitination PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
S533 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163
S546 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus   UniProt 23186163
T567 Phosphorylation PhosphoSitePlus
S582 Phosphorylation PhosphoSitePlus
S589 Phosphorylation IEDB   PhosphoSitePlus   UniProt 23186163, 32387766
S671 Phosphorylation PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
T733 Phosphorylation PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
S737 Phosphorylation PhosphoSitePlus
K745 Ubiquitination PhosphoSitePlus
K765 Ubiquitination PhosphoSitePlus
K787 Ubiquitination PhosphoSitePlus
T832 Phosphorylation PhosphoSitePlus   UniProt 24275569
K834 Ubiquitination PhosphoSitePlus
K874 Ubiquitination PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus
S923 Phosphorylation PhosphoSitePlus
S925 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 19691289, ...19664995, 18669648, 19007248, 20068231
K934 Ubiquitination PhosphoSitePlus
S939 Phosphorylation PhosphoSitePlus
S943 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S944 Phosphorylation PhosphoSitePlus
S958 Phosphorylation PhosphoSitePlus   UniProt 19690332
S960 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
T1041 Phosphorylation PhosphoSitePlus
K1052 Ubiquitination PhosphoSitePlus
K1078 Ubiquitination PhosphoSitePlus
K1218 Acetylation PhosphoSitePlus   UniProt 19608861
T1248 Phosphorylation PhosphoSitePlus
S1249 Phosphorylation PhosphoSitePlus
S1303 Phosphorylation PhosphoSitePlus
S1470 Phosphorylation HPRD   PhosphoSitePlus 18452278
S1588 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
T1610 Phosphorylation PhosphoSitePlus
T1612 Phosphorylation PhosphoSitePlus
T1614 Phosphorylation PhosphoSitePlus
S1617 Phosphorylation PhosphoSitePlus
T1620 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T1642 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19690332, 20068231
T1675 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S1682 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S1692 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S1697 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1699 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S1701 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S1712 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1720 Phosphorylation PhosphoSitePlus
Y1756 Phosphorylation PhosphoSitePlus
S1760 Phosphorylation PhosphoSitePlus
T1798 O-Glycosylation GlyGen 23301498, 30379171, 35289036, ...35254053
T1809 Phosphorylation PhosphoSitePlus
S1811 Phosphorylation PhosphoSitePlus
S1812 Phosphorylation PhosphoSitePlus
S1813 Phosphorylation PhosphoSitePlus
S1838 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1840 Phosphorylation PhosphoSitePlus
T1852 Phosphorylation PhosphoSitePlus
S1854 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19664994, 19691289, 19007248, 18669648, 19690332, 20068231
T1859 Phosphorylation PhosphoSitePlus
S1888 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1890 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19664995
S1891 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648, 19664995
S1895 Phosphorylation PhosphoSitePlus
S1903 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 19664995, ...18669648, 24275569, 19690332
T1907 Phosphorylation PhosphoSitePlus
S1926 Phosphorylation PhosphoSitePlus
C2001 Methylation IEDB 31844290
K2147 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K57 T57 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S83 Y83 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K163 R163 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K163 N163 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K201 R201 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S393 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S452 F452 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S452 C452 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S457 Y457 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K483 R483 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T484 A484 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S532 F532 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S558 L558 Biomuta DOID:4159 / skin cancer [ cosmic ]
S582 F582 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S707 R707 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S737 L737 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S923 R923 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S939 Y939 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S944 L944 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1248 R1248 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1303 G1303 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T1610 A1610 Biomuta DOID:1319 / brain cancer [ icgc ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S1697 F1697 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1701 C1701 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1701 Y1701 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1760 P1760 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1813 Y1813 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1926 F1926 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1926 P1926 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]