Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y285 / SYFA_HUMAN
Protein Name Phenylalanine--tRNA ligase alpha subunit
Gene Name Name: FARSA
Synonyms:FARS,FARSL,FARSLA;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y285
DAG View
PRO Name phenylalanine--tRNA ligase alpha subunit (human)
Definition A eukaryote-type phenylalanine--tRNA ligase alpha subunit that is encoded in the genome of human.
Short Label hFARSA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y285 (FARSA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895, ...25944712
R12 Methylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K117 Acetylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
R124 Methylation PhosphoSitePlus
R144 Methylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
T190 Phosphorylation PhosphoSitePlus   UniProt 23186163
S193 Phosphorylation PhosphoSitePlus   UniProt 18691976
K208 Ubiquitination PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
Y292 Phosphorylation PhosphoSitePlus
K297 Acetylation PhosphoSitePlus
T299 Phosphorylation PhosphoSitePlus
S301 Phosphorylation Q13535 (ATR) PhosphoSitePlus 18077418
Y305 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
Y310 Phosphorylation PhosphoSitePlus
K311 Acetylation PhosphoSitePlus   UniProt 19608861
K311 Sumoylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
T346 Phosphorylation PhosphoSitePlus
K349 Acetylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
Y350 Phosphorylation PhosphoSitePlus
R355 Methylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
Y488 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
T504 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S193 Phosphorylation HPRD 18691976, 20068231
S301 Phosphorylation HPRD 18077418


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R124 L124 Biomuta DOID:1790 / malignant mesothelioma [ tcga ]
R124 Q124 Biomuta DOID:4362 / cervical cancer [ tcga ]
R144 W144 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R144 Q144 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S184 R184 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S307 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]