iPTMnet Report for Q9Y262 (EIF3L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y262 / EIF3L_HUMAN
Protein Name Eukaryotic translation initiation factor 3 subunit L
Gene Name Name: EIF3L
Synonyms:EIF3EIP;ORFNames:HSPC021,HSPC025,MSTP005;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y262
DAG View
PRO Name eukaryotic translation initiation factor 3 subunit L (human)
Definition A eukaryotic translation initiation factor 3 subunit L that is encoded in the genome of human.
Short Label hEIF3L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y262 (EIF3L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22223895, 17322308
S2 Phosphorylation PhosphoSitePlus
Y14 Phosphorylation PhosphoSitePlus
Y17 Phosphorylation PhosphoSitePlus
Y19 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y23 Phosphorylation PhosphoSitePlus
Y36 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
T44 Phosphorylation PhosphoSitePlus
Y45 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
Y89 Phosphorylation PhosphoSitePlus
Y95 Phosphorylation PhosphoSitePlus
K101 Acetylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
C161 Methylation IEDB 31844290
K206 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus
Y287 Phosphorylation PhosphoSitePlus
Y288 Phosphorylation PhosphoSitePlus
K301 Acetylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
C311 Methylation IEDB 31844290
Y342 Phosphorylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
Y357 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
Y409 Phosphorylation PhosphoSitePlus
Y415 Phosphorylation PhosphoSitePlus
C417 Methylation IEDB 31844290
K419 Ubiquitination PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
K437 Acetylation PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
K445 Acetylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
K465 Acetylation PhosphoSitePlus   UniProt 19608861
K465 Ubiquitination PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
Y539 Phosphorylation PhosphoSitePlus
K549 Acetylation PhosphoSitePlus   UniProt 19608861
K549 Ubiquitination PhosphoSitePlus
T556 Phosphorylation PhosphoSitePlus
K558 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S80 Phosphorylation HPRD 18452278
S81 Phosphorylation HPRD 18452278
Y95 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 F2 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y89 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y287 C287 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T376 M376 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K397 N397 Biomuta DOID:4362 / cervical cancer [ cosmic ]
Y415 H415 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K419 N419 Biomuta DOID:1324 / lung cancer [ cosmic ]
S422 L422 Biomuta DOID:9256 / colorectal cancer [ cosmic ]