iPTMnet Report for Q9Y252 (RNF6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y252 / RNF6_HUMAN
Protein Name E3 ubiquitin-protein ligase RNF6
Gene Name Name: RNF6
Synonyms:SPG2;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y252
DAG View
PRO Name E3 ubiquitin-protein ligase RNF6 (human)
Definition An E3 ubiquitin-protein ligase RNF6 that is encoded in the genome of human.
Short Label hRNF6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y252 (RNF6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
T133 Phosphorylation PhosphoSitePlus
R220 Methylation PhosphoSitePlus
R236 Methylation PhosphoSitePlus
R247 Methylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
Y364 Phosphorylation PhosphoSitePlus
T365 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
T389 Phosphorylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
T461 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
C632 Methylation IEDB 31844290
K644 Ubiquitination PhosphoSitePlus
C650 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 L6 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R220 G220 Biomuta DOID:1319 / brain cancer [ cosmic ]
R247 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T389 S389 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T459 A459 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K644 N644 Biomuta DOID:1324 / lung cancer [ cosmic ]
K644 * Biomuta DOID:1324 / lung cancer [ cosmic ]