iPTMnet Report for Q9Y251 (HPSE)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y251 / HPSE_HUMAN
Protein Name Heparanase precursor
Gene Name Name: HPSE
Synonyms:HEP,HPA,HPA1,HPR1,HPSE1,HSE1;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y251
DAG View
PRO Name heparanase (human)
Definition A heparanase that is encoded in the genome of human.
Short Label hHPSE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y251 (HPSE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K98 Acetylation PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus
N162 N-Glycosylation GlyGen   UniProt 28581485, 14573609, 24190977
Y165 Phosphorylation PhosphoSitePlus
N178 N-Glycosylation GlyGen   UniProt 14573609
N200 N-Glycosylation GlyGen   UniProt 28581485, 14573609
N217 N-Glycosylation GlyGen   UniProt 16263699, 28581485, 14573609, ...19159218, 24190977
N238 N-Glycosylation GlyGen   UniProt 28581485, 14573609, 19159218, ...24190977
K262 Ubiquitination PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
Y348 Phosphorylation PhosphoSitePlus
K427 Acetylation PhosphoSitePlus
N456 N-Glycosylation GlyGen 24190977
N459 N-Glycosylation GlyGen   UniProt 28581485, 14573609, 24190977
T507 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T99 Phosphorylation HPRD 20068231
T507 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T99 I99 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y348 H348 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y348 C348 Biomuta DOID:363 / uterine cancer [ icgc ]
K427 N427 Biomuta DOID:4159 / skin cancer [ cosmic ]