Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y233 / PDE10_HUMAN
Protein Name cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Gene Name Name: PDE10A
Organism Homo sapiens (Human)

PRO ID PR:Q9Y233
DAG View
PRO Name cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (human)
Definition A cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A that is encoded in the genome of human.
Short Label hPDE10A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y233 (PDE10A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
T15 Phosphorylation P17612 (PRKACA) Signor 20610737
T88 Phosphorylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
T363 Phosphorylation PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
Y639 Phosphorylation PhosphoSitePlus
T661 Phosphorylation PhosphoSitePlus
T669 Phosphorylation PhosphoSitePlus
K754 Ubiquitination PhosphoSitePlus
S767 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S766 Phosphorylation HPRD 18691976
S767 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
T16 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 20610737
K28 Ubiquitination PhosphoSitePlus
Y649 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T15 P15 Biomuta DOID:1909 / melanoma [ cosmic ]
T363 I363 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
T661 S661 Biomuta DOID:1324 / lung cancer [ cosmic ]
T669 K669 Biomuta DOID:5041 / esophageal cancer [ icgc ]
T669 S669 Biomuta DOID:1324 / lung cancer [ tcga ]
S766 L766 Biomuta DOID:1612 / breast cancer [ tcga ] DOID:1324 / lung cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc, tcga ]
S767 Y767 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]