Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y230 / RUVB2_HUMAN
Protein Name RuvB-like 2
Gene Name Name: RUVBL2
Synonyms:INO80J,TIP48,TIP49B;ORFNames:CGI-46;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y230
DAG View
PRO Name RuvB-like 2 (human)
Definition A RuvB-like 2 that is encoded in the genome of human.
Short Label hRUVBL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y230 (RUVBL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 25944712
K9 Ubiquitination PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
R29 Methylation PhosphoSitePlus
T81 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
T170 Phosphorylation PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
S220 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
T222 Phosphorylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
C227 S-Nitrosylation dbSNO 26338901
K234 Acetylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
K269 Sumoylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
R336 Methylation PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
Y340 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
R353 Methylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
K365 Acetylation PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K417 Acetylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
T419 Phosphorylation PhosphoSitePlus
K427 Acetylation PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
Y430 Phosphorylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus   UniProt 23186163
K444 Ubiquitination PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
K456 Sumoylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation HPRD 20068231
S26 Phosphorylation HPRD 20068231
S220 Phosphorylation HPRD 17525332
S262 Phosphorylation HPRD 19651622
T265 Phosphorylation HPRD 19651622
T338 Phosphorylation HPRD 18452278
S339 Phosphorylation HPRD 18452278
Y340 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K9 E9 Biomuta DOID:2994 / germ cell cancer [ tcga ]
R29 Q29 Biomuta DOID:1909 / melanoma [ cosmic ]
S110 F110 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S110 P110 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K184 N184 Biomuta DOID:3571 / liver cancer [ icgc ]
K223 R223 Biomuta DOID:3571 / liver cancer [ tcga ]
R336 W336 Biomuta DOID:9256 / colorectal cancer [ tcga ]
R353 W353 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S358 C358 Biomuta DOID:1324 / lung cancer [ cosmic ]
S431 L431 Biomuta DOID:1612 / breast cancer [ cosmic ]